Methamphetamine induces transcriptional changes in cultured HIV-infected mature monocytes that may contribute to HIV neuropathogenesis

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Fältnamn	Indikatorer	Metadata
000		04400naa a2200469 4500
001		oai:DiVA.org:uu-484902
003		SwePub
008		220920s2022 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4849022 URI
024	7	a https://doi.org/10.3389/fimmu.2022.9521832 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Chilunda, Vanessau Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA.4 aut
245	1 0	a Methamphetamine induces transcriptional changes in cultured HIV-infected mature monocytes that may contribute to HIV neuropathogenesis
264		c 2022-08-18
264	1	b Frontiers Media S.A.c 2022
338		a electronic2 rdacarrier
520		a HIV-associated neurocognitive impairment (HIV-NCI) persists in 15-40% of people with HIV (PWH) despite effective antiretroviral therapy. HIV-NCI significantly impacts quality of life, and there is currently no effective treatment for it. The development of HIV-NCI is complex and is mediated, in part, by the entry of HIV-infected mature monocytes into the central nervous system (CNS). Once in the CNS, these cells release inflammatory mediators that lead to neuroinflammation, and subsequent neuronal damage. Infected monocytes may infect other CNS cells as well as differentiate into macrophages, thus contributing to viral reservoirs and chronic neuroinflammation. Substance use disorders in PWH, including the use of methamphetamine (meth), can exacerbate HIV neuropathogenesis. We characterized the effects of meth on the transcriptional profile of HIV-infected mature monocytes using RNA-sequencing. We found that meth mediated an upregulation of gene transcripts related to viral infection, cell adhesion, cytoskeletal arrangement, and extracellular matrix remodeling. We also identified downregulation of several gene transcripts involved in pathogen recognition, antigen presentation, and oxidative phosphorylation pathways. These transcriptomic changes suggest that meth increases the infiltration of mature monocytes that have a migratory phenotype into the CNS, contributing to dysregulated inflammatory responses and viral reservoir establishment and persistence, both of which contribute to neuronal damage. Overall, our results highlight potential molecules that may be targeted for therapy to limit the effects of meth on HIV neuropathogenesis.
650	7	a NATURVETENSKAPx Biologix Immunologi0 (SwePub)106052 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciencesx Immunology0 (SwePub)106052 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
653		a methamphetamine
653		a monocytes
653		a HIV
653		a neuroinflammation
653		a migration
653		a viral reservoirs
700	1	a Weiselberg, Jessicau Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA.4 aut
700	1	a Martinez-Meza, Samuelu Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA.4 aut
700	1	a Mhamilawa, Lwidiko Eu Uppsala universitet,Internationell barnhälsa och nutrition,Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA.;Muhimbili Univ Hlth & Allied Sci, Dept Parasitol & Med Entomol, Dar Es Salaam, Tanzania.4 aut0 (Swepub:uu)lwied894
700	1	a Cheney, Laurau Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA.;Montefiore Med Ctr, Dept Med, Div Infect Dis, Bronx, NY USA.;Albert Einstein Coll Med, Bronx, NY 10467 USA.4 aut
700	1	a Berman, Joan W.u Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA.;Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA.4 aut
710	2	a Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA.b Internationell barnhälsa och nutrition4 org
773	0	t Frontiers in Immunologyd : Frontiers Media S.A.g 13q 13x 1664-3224
856	4	u https://doi.org/10.3389/fimmu.2022.952183y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1697445/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-484902
856	4 8	u https://doi.org/10.3389/fimmu.2022.952183

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Av författaren/redakt...: Chilunda, Vaness ...; Weiselberg, Jess ...; Martinez-Meza, S ...; Mhamilawa, Lwidi ...; Cheney, Laura; Berman, Joan W.

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