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Endothelium-derived...
Endothelium-derived lactate is required for pericyte function and blood-brain barrier maintenance
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- Lee, Heon-Woo (författare)
- Yale Univ, Sch Med, Dept Internal Med, Yale Cardiovasc Res Ctr,Sect Cardiovasc Med, New Haven, CT 06510 USA
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- Xu, Yanying (författare)
- Yale Univ, Sch Med, Dept Internal Med, Yale Cardiovasc Res Ctr,Sect Cardiovasc Med, New Haven, CT 06510 USA.;Cent South Univ, Xiangya Hosp, Dept Cardiovasc Med, Changsha, Peoples R China
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- Zhu, Xiaolong (författare)
- Yale Univ, Sch Med, Dept Internal Med, Yale Cardiovasc Res Ctr,Sect Cardiovasc Med, New Haven, CT 06510 USA
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- Jang, Cholsoon (författare)
- Univ Calif Irvine, Dept Biol Chem, Irvine, CA 92717 USA
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- Choi, Woosung (författare)
- Gwangju Inst Sci & Technol GIST, Sch Life Sci, Gwangju, South Korea.;Gwangju Inst Sci & Technol GIST, Cell Logist Res Ctr, Gwangju, South Korea
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- Bae, Hosung (författare)
- Univ Calif Irvine, Dept Biol Chem, Irvine, CA 92717 USA
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- Wang, Weiwei (författare)
- Yale Univ, Sch Med, WM Keck Biotechnol Resource Lab, New Haven, CT USA
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- He, Liqun (författare)
- Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab
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- Jin, Suk-Won (författare)
- Yale Univ, Sch Med, Dept Internal Med, Yale Cardiovasc Res Ctr,Sect Cardiovasc Med, New Haven, CT 06510 USA.;Gwangju Inst Sci & Technol GIST, Sch Life Sci, Gwangju, South Korea.;Gwangju Inst Sci & Technol GIST, Cell Logist Res Ctr, Gwangju, South Korea
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- Arany, Zoltan (författare)
- Univ Penn, Perelman Sch Med, Cardiovasc Inst, Philadelphia, PA 19104 USA
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- Simons, Michael (författare)
- Yale Univ, Sch Med, Dept Internal Med, Yale Cardiovasc Res Ctr,Sect Cardiovasc Med, New Haven, CT 06510 USA.;Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06510 USA
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Yale Univ, Sch Med, Dept Internal Med, Yale Cardiovasc Res Ctr,Sect Cardiovasc Med, New Haven, CT 06510 USA Yale Univ, Sch Med, Dept Internal Med, Yale Cardiovasc Res Ctr,Sect Cardiovasc Med, New Haven, CT 06510 USA;Cent South Univ, Xiangya Hosp, Dept Cardiovasc Med, Changsha, Peoples R China (creator_code:org_t)
- 2022-03-03
- 2022
- Engelska.
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Ingår i: EMBO Journal. - : EMBO Press. - 0261-4189 .- 1460-2075. ; 41:9
- Relaterad länk:
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https://www.embopres...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Endothelial cells differ from other cell types responsible for the formation of the vascular wall in their unusual reliance on glycolysis for most energy needs, which results in extensive production of lactate. We find that endothelium-derived lactate is taken up by pericytes, and contributes substantially to pericyte metabolism including energy generation and amino acid biosynthesis. Endothelial-pericyte proximity is required to facilitate the transport of endothelium-derived lactate into pericytes. Inhibition of lactate production in the endothelium by deletion of the glucose transporter-1 (GLUT1) in mice results in loss of pericyte coverage in the retina and brain vasculatures, leading to the blood-brain barrier breakdown and increased permeability. These abnormalities can be largely restored by oral lactate administration. Our studies demonstrate an unexpected link between endothelial and pericyte metabolisms and the role of endothelial lactate production in the maintenance of the blood-brain barrier integrity. In addition, our observations indicate that lactate supplementation could be a useful therapeutic approach for GLUT1 deficiency metabolic syndrome patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- BBB permeability
- endothelial metabolism
- Glucose
- lactate
- pericyte metabolism
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Lee, Heon-Woo
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Xu, Yanying
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Zhu, Xiaolong
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Jang, Cholsoon
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Choi, Woosung
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Bae, Hosung
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visa fler...
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Wang, Weiwei
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He, Liqun
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Jin, Suk-Won
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Arany, Zoltan
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Simons, Michael
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visa färre...
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