Postpartum depression: a developed and validated model predicting individual risk in new mothers

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Postpartum depression : a developed and validated model predicting individual risk in new mothers

Munk-Olsen, Trine (författare): Univ Southern Denmark, Dept Clin Res, Odense, Denmark.;Aarhus Univ, Natl Ctr Register Based Res, Aarhus BSS, Aarhus, Denmark.

Liu, Xiaoqin (författare): Aarhus Univ, Natl Ctr Register Based Res, Aarhus BSS, Aarhus, Denmark.

Madsen, Kathrine Bang (författare): Aarhus Univ, Natl Ctr Register Based Res, Aarhus BSS, Aarhus, Denmark.

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Kjeldsen, Mette-Marie Zacher (författare): Aarhus Univ, Natl Ctr Register Based Res, Aarhus BSS, Aarhus, Denmark.

Petersen, Liselotte Vogdrup (författare): Aarhus Univ, Natl Ctr Register Based Res, Aarhus BSS, Aarhus, Denmark.

Bergink, Veerle (författare): Erasmus MC, Dept Psychiat, Rotterdam, Netherlands.;Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY USA.

Skalkidou, Alkistis, 1977- (författare): Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning

Vigod, Simone N. (författare): Univ Toronto, Dept Psychiat, Womens Coll Hosp, Toronto, ON, Canada.

Frokjaer, Vibe G. (författare): Univ Toronto, Dept Psychiat, Womens Coll Res Inst, Toronto, ON, Canada.;Capital Reg Denmark, Mental Hlth Serv, Copenhagen, Denmark.;Copenhagen Univ Hosp, Neurobiol Res Unit, Copenhagen, Denmark.

Pedersen, Carsten B. (författare): Aarhus Univ, Natl Ctr Register Based Res, Aarhus BSS, Aarhus, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark.;Aarhus Univ, Ctr Integrated Register Based Res, CIRRAU, Aarhus, Denmark.

Maegbaek, Merete L. (författare): Aarhus Univ, Natl Ctr Register Based Res, Aarhus BSS, Aarhus, Denmark.

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Univ Southern Denmark, Dept Clin Res, Odense, Denmark;Aarhus Univ, Natl Ctr Register Based Res, Aarhus BSS, Aarhus, Denmark. Aarhus Univ, Natl Ctr Register Based Res, Aarhus BSS, Aarhus, Denmark. (creator_code:org_t)

2022-09-30
2022
Engelska.
Ingår i: Translational Psychiatry. - : Springer Nature. - 2158-3188. ; 12:1

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://uu.diva-port... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

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Postpartum depression (PPD) is a serious condition associated with potentially tragic outcomes, and in an ideal world PPDs should be prevented. Risk prediction models have been developed in psychiatry estimating an individual's probability of developing a specific condition, and recently a few models have also emerged within the field of PPD research, although none are implemented in clinical care. For the present study we aimed to develop and validate a prediction model to assess individualized risk of PPD and provide a tentative template for individualized risk calculation offering opportunities for additional external validation of this tool. Danish population registers served as our data sources and PPD was defined as recorded contact to a psychiatric treatment facility (ICD-10 code DF32-33) or redeemed antidepressant prescriptions (ATC code N06A), resulting in a sample of 6,402 PPD cases (development sample) and 2,379 (validation sample). Candidate predictors covered background information including cohabitating status, age, education, and previous psychiatric episodes in index mother (Core model), additional variables related to pregnancy and childbirth (Extended model), and further health information about the mother and her family (Extended+ model). Results indicated our recalibrated Extended model with 14 variables achieved highest performance with satisfying calibration and discrimination. Previous psychiatric history, maternal age, low education, and hyperemesis gravidarum were the most important predictors. Moving forward, external validation of the model represents the next step, while considering who will benefit from preventive PPD interventions, as well as considering potential consequences from false positive and negative test results, defined through different threshold values.

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Av författaren/redakt...: Munk-Olsen, Trin ...; Liu, Xiaoqin; Madsen, Kathrine ...; Kjeldsen, Mette- ...; Petersen, Liselo ...; Bergink, Veerle; visa fler...; Skalkidou, Alkis ...; Vigod, Simone N.; Frokjaer, Vibe G ...; Pedersen, Carste ...; Maegbaek, Merete ...; visa färre...

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Postpartum depression : a developed and validated model predicting individual risk in new mothers

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