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Bidirectional Assoc...
Bidirectional Association between Major Depressive Disorder and Gastroesophageal Reflux Disease : Mendelian Randomization Study
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- Miao, Yuyang (author)
- Tianjin Med Univ, Dept Geriatr, Gen Hosp, Tianjin 300052, Peoples R China.;Tianjin Geriatr Inst, Tianjin 300052, Peoples R China.
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- Yuan, Shuai (author)
- Karolinska Institutet
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- Li, Ye (author)
- Tianjin Med Univ, Dept Geriatr, Gen Hosp, Tianjin 300052, Peoples R China.;Tianjin Geriatr Inst, Tianjin 300052, Peoples R China.
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- Chen, Jie (author)
- Zhejiang Univ, Ctr Global Hlth, Sch Med, Hangzhou 310030, Peoples R China.;Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha 410017, Peoples R China.
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- Li, Xue (author)
- Zhejiang Univ, Sch Med, Sch Publ Hlth, Hangzhou 310030, Peoples R China.;Zhejiang Univ, Sch Med, Affiliated Hosp 2, Hangzhou 310030, Peoples R China.;Univ Edinburgh, Usher Inst, Ctr Global Hlth, Edinburgh EH8 9YL, Midlothian, Scotland.
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- Larsson, Susanna C. (author)
- Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Inst Environm Med, Karolinska Inst, Unit Cardiovasc & Nutr Epidemiol, S-17177 Stockholm, Sweden.
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- Zhang, Qiang (author)
- Tianjin Med Univ, Dept Geriatr, Gen Hosp, Tianjin 300052, Peoples R China.;Tianjin Geriatr Inst, Tianjin 300052, Peoples R China.
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Karolinska Institutet Tianjin Med Univ, Dept Geriatr, Gen Hosp, Tianjin 300052, Peoples R China;Tianjin Geriatr Inst, Tianjin 300052, Peoples R China. (creator_code:org_t)
- 2022-11-02
- 2022
- English.
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In: Genes. - : MDPI. - 2073-4425. ; 13:11
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Abstract
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- Background: Observational research has found a bidirectional relationship between major depressive disorder and gastroesophageal reflux disease; however, the causal association of this relationship is undetermined. Aims: A bidirectional Mendelian randomization study was performed to explore the causal relationships between major depressive disorder and gastroesophageal reflux disease. Methods: For the instrumental variables of major depressive disorder and gastroesophageal reflux disease, 31 and 24 single-nucleotide polymorphisms without linkage disequilibrium (r(2) <= 0.001) were selected from relevant genome-wide association studies, respectively, at the genome-wide significance level (p <= 5 x 10(-8)). We sorted summary-level genetic data for major depressive disorder, gastroesophageal reflux disease, gastroesophageal reflux disease without esophagitis, and reflux esophagitis from meta-analysis study of genome-wide association studies involving 173,005 individuals (59,851 cases and 113,154 non-cases), 385,276 individuals (80,265 cases and 305,011 non-cases), 463,010 individuals (4360 cases and 458,650 non-cases), and 383,916 individuals (12,567 cases and 371,349 non-cases), respectively. Results: Genetic liability to major depressive disorder was positively associated with gastroesophageal reflux disease and its subtypes. Per one-unit increase in log-transformed odds ratio of major depressive disorder, the odds ratio was 1.31 (95% confidence interval [CI], 1.19-1.43; p = 1.64 x 10(-8)) for gastroesophageal reflux disease, 1.51 (95% CI, 1.15-1.98; p = 0.003) for gastroesophageal reflux disease without esophagitis, and 1.21 (95% CI, 1.05-1.40; p = 0.010) for reflux esophagitis. Reverse-direction analysis suggested that genetic liability to gastroesophageal reflux disease was causally related to increasing risk of major depressive disorder. Per one-unit increase in log-transformed odds ratio of gastroesophageal reflux disease, the odds ratio of major depressive disorder was 1.28 (95% confidence interval, 1.11-1.47; p = 1.0 x 10(-3)). Conclusions: This Mendelian randomization study suggests a bidirectional causal relationship between major depressive disorder and gastroesophageal reflux disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- gastroesophageal reflux disease
- major depressive disorder
- Mendelian randomization analysis
Publication and Content Type
- ref (subject category)
- art (subject category)
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