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The next wave of interactomics : Mapping the SLiM-based interactions of the intrinsically disordered proteome
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- Davey, Norman E. (author)
- Inst Canc Res, Div Canc Biol, 237 Fulham Rd, London SW3 6JB, England.
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- Simonetti, Leandro (author)
- Uppsala universitet,Biokemi
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- Ivarsson, Ylva (author)
- Uppsala universitet,Biokemi
- Inst Canc Res, Div Canc Biol, 237 Fulham Rd, London SW3 6JB, England Biokemi (creator_code:org_t)
- Elsevier BV, 2023
- 2023
- English.
- In: Current opinion in structural biology. - : Elsevier BV. - 0959-440X .- 1879-033X. ; 80
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Short linear motifs (SLiMs) are a unique and ubiquitous class of protein interaction modules that perform key regulatory functions and drive dynamic complex formation. For decades, interactions mediated by SLiMs have accumulated through detailed low-throughput experiments. Recent methodological advances have opened this previously underexplored area of the human interactome to high-throughput protein-protein interaction discovery. In this article, we discuss that SLiM-based interactions represent a significant blind spot in the current interactomics data, introduce the key methods that are illuminating the elusive SLiM-mediated interactome of the human cell on a large scale, and discuss the implications for the field.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- Short linear motifs (SLiMs)
- Protein-protein interactions
- Interactomics
- High-throughput methods
- Protein-peptide interactions
Publication and Content Type
- ref (subject category)
- art (subject category)
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