Search: id:"swepub:oai:DiVA.org:uu-504200" >
Fish oil supplement...
Fish oil supplementation during pregnancy and postpartum in mothers with overweight and obesity to improve body composition and metabolic health during infancy : A double-blind randomized controlled trial
-
- V. Satokar, Vidit (author)
- Univ Auckland, Liggins Inst, Auckland, New Zealand.
-
- Derraik, José G. B. (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Univ Auckland, Liggins Inst, Auckland, New Zealand.;Univ Auckland, Fac Med & Hlth Sci, Dept Paediatrics: Child & Youth Hlth, Auckland, New Zealand.;Chiang Mai Univ, Res Inst Hlth Sci, Environm Occupat Hlth Sci & Noncommunicable Dis Re, Chiang Mai, Thailand.
-
- Harwood, Matire (author)
- Univ Auckland, Dept Gen Practice & Primary Care, Auckland, New Zealand.
-
show more...
-
- Okesene-Gafa, Karaponi (author)
- Univ Auckland, Fac Med & Hlth Sci, Dept Obstet & Gynaecol, Auckland, New Zealand.
-
- Beck, Kathryn (author)
- Massey Univ, Coll Hlth, Sch Sport Exercise & Nutr, Auckland, New Zealand.
-
- Cameron-Smith, David (author)
- Univ Auckland, Liggins Inst, Auckland, New Zealand.;Univ Newcastle, Coll Engn Sci & Environm, Callaghan, NSW, Australia.;Univ Newcastle, Coll Hlth Med & Wellbeing, Sch Biomed Sci & Pharm, Callaghan, NSW, Australia.
-
- Garg, Manohar L. (author)
- Univ Newcastle, Coll Hlth Med & Wellbeing, Sch Biomed Sci & Pharm, Callaghan, NSW, Australia.
-
- O'Sullivan, Justin M. (author)
- Univ Auckland, Liggins Inst, Auckland, New Zealand.
-
- Sundborn, Gerhard (author)
- Univ Auckland, Liggins Inst, Auckland, New Zealand.;Univ Auckland, Sch Populat Hlth, Dept Pacific Hlth, Auckland, New Zealand.
-
- Pundir, Shikha (author)
- Univ Auckland, Liggins Inst, Auckland, New Zealand.
-
- Mason, R. Preston (author)
- Univ Auckland, Liggins Inst, Auckland, New Zealand.;Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Cardiovasc Div, Boston, MA USA.
-
- Cutfield, Wayne S. (author)
- Univ Auckland, Liggins Inst, Auckland, New Zealand.;Univ Auckland, Fac Med & Hlth Sci, Dept Paediatrics: Child & Youth Hlth, Auckland, New Zealand.;Univ Auckland, Natl Sci Challenge, Auckland, New Zealand.
-
- Albert, Benjamin B. (author)
- Univ Auckland, Liggins Inst, Auckland, New Zealand.;Univ Auckland, Fac Med & Hlth Sci, Dept Paediatrics: Child & Youth Hlth, Auckland, New Zealand.;Univ Auckland, Natl Sci Challenge, Auckland, New Zealand.
-
show less...
-
Univ Auckland, Liggins Inst, Auckland, New Zealand Institutionen för kvinnors och barns hälsa (creator_code:org_t)
- Elsevier BV, 2023
- 2023
- English.
-
In: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165 .- 1938-3207. ; 117:5, s. 883-895
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Background: Maternal obesity during pregnancy is associated with an increased risk of obesity and metabolic disease in the offspring. Supplementation with fish oil (FO), which is insulin sensitizing, during pregnancy in mothers with overweight or obesity may prevent the development of greater adiposity and metabolic dysfunction in their children.Objectives: To determine the effects of FO supplementation throughout the second half of pregnancy and lactation in mothers with overweight or obesity on infant body composition and metabolism.Methods: A double-blind randomized controlled trial of 6 g FO (3.55 g/d of n-3 PUFAs) compared with olive oil (control) from mid-pregnancy until 3 mo postpartum. Eligible women had singleton pregnancies at 12-20 wk of gestation, and BMI >= 25 kg/m2. The primary outcome was the infant body fat percentage (DXA scans) at 2 wk of age. Secondary outcomes included maternal metabolic markers during pregnancy, infant anthropometry at 2 wk and 3 mo of age, and metabolic markers at 3 mo.Results: A total of 129 mothers were randomized, and 98 infants had a DXA scan at 2 wk. Primary outcome: Imputed and nonimputed analyses showed no effects of FO supplementation on infant body fat percentage at age 2 wk. Secondary outcomes: There were no treatment effects on infant outcomes at 2 wk, but FO infants had a higher BMI z-score (P = 0.025) and ponderal index (P = 0.017) at age 3 mo. FO supplementation lowered maternal tri-glycerides by 17% at 30 wk of pregnancy (P = 0.0002) and infant triglycerides by 21% at 3 mo of age (P = 0.016) but did not affect maternal or infant insulin resistance. The rate of emergency cesarean section was lower with FO supplementation [aRR = 0.38 (95%CI 0.16, 0.90); P = 0.027].Conclusions: FO supplementation of mothers with overweight or obesity during pregnancy did not impact infant body composition. There is a need to follow up the offspring to determine whether the observed metabolic effects persist. Clinical trial registry number: This study was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12617001078347p). In addition, the Universal Trial Number, WHO, was obtained (U1111-1199-5860).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- fish oil supplementation
- maternal overweight
- obesity
- n-3 polyunsaturated fatty acids
- pregnancy
- triglycerides
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
V. Satokar, Vidi ...
-
Derraik, José G. ...
-
Harwood, Matire
-
Okesene-Gafa, Ka ...
-
Beck, Kathryn
-
Cameron-Smith, D ...
-
show more...
-
Garg, Manohar L.
-
O'Sullivan, Just ...
-
Sundborn, Gerhar ...
-
Pundir, Shikha
-
Mason, R. Presto ...
-
Cutfield, Wayne ...
-
Albert, Benjamin ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Pediatrics
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Nutrition and Di ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Obstetrics Gynae ...
- Articles in the publication
-
American Journal ...
- By the university
-
Uppsala University