Search: id:"swepub:oai:DiVA.org:uu-507474" >
Prediction model fo...
Prediction model for drug response of acute myeloid leukemia patients
-
- Trac, Quang Thinh (author)
- Karolinska Institutet
-
- Pawitan, Yudi (author)
- Karolinska Institutet
-
- Mou, Tian (author)
- Shenzhen Univ, Sch Biomed Engn, Shenzhen, Peoples R China.
-
show more...
-
- Erkers, Tom (author)
- Karolinska Institutet
-
- Östling, Päivi (author)
- Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, Stockholm, Sweden.;Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland.
-
- Bohlin, Anna (author)
- Karolinska Univ, Karolinska Inst,Hosp Huddinge, Dept Med Huddinge, Unit Hematol, Stockholm, Sweden.
-
- Österroos, Albin (author)
- Uppsala universitet,Hematologi
-
- Vesterlund, Mattias (author)
- Karolinska Institutet
-
- Jafari, Rozbeh (author)
- Karolinska Institutet
-
- Siavelis, Ioannis (author)
- Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, Stockholm, Sweden.
-
- Bäckvall, Helena (author)
- Karolinska Institutet
-
- Kiviluoto, Santeri (author)
- Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, Stockholm, Sweden.
-
- Orre, Lukas M. (author)
- Karolinska Institutet
-
- Rantalainen, Mattias (author)
- Karolinska Institutet
-
- Lehtiö, Janne (author)
- Karolinska Institutet
-
- Lehmann, Sören (author)
- Uppsala universitet,Hematologi,Karolinska Univ, Karolinska Inst,Hosp Huddinge, Dept Med Huddinge, Unit Hematol, Stockholm, Sweden.
-
- Kallioniemi, Olli (author)
- Karolinska Institutet
-
- Vu, Trung Nghia (author)
- Karolinska Institutet
-
show less...
-
Karolinska Institutet Shenzhen Univ, Sch Biomed Engn, Shenzhen, Peoples R China (creator_code:org_t)
- 2023-03-24
- 2023
- English.
-
In: npj Precision Oncology. - : Springer Nature. - 2397-768X. ; 7
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Despite some encouraging successes, predicting the therapy response of acute myeloid leukemia (AML) patients remains highly challenging due to tumor heterogeneity. Here we aim to develop and validate MDREAM, a robust ensemble-based prediction model for drug response in AML based on an integration of omics data, including mutations and gene expression, and large-scale drug testing. Briefly, MDREAM is first trained in the BeatAML cohort (n = 278), and then validated in the BeatAML (n = 183) and two external cohorts, including a Swedish AML cohort (n = 45) and a relapsed/refractory acute leukemia cohort (n = 12). The final prediction is based on 122 ensemble models, each corresponding to a drug. A confidence score metric is used to convey the uncertainty of predictions; among predictions with a confidence score >0.75, the validated proportion of good responders is 77%. The Spearman correlations between the predicted and the observed drug response are 0.68 (95% CI: [0.64, 0.68]) in the BeatAML validation set, -0.49 (95% CI: [-0.53, -0.44]) in the Swedish cohort and 0.59 (95% CI: [0.51, 0.67]) in the relapsed/refractory cohort. A web-based implementation of MDREAM is publicly available at https://www.meb.ki.se/shiny/truvu/MDREAM/.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Trac, Quang Thin ...
-
Pawitan, Yudi
-
Mou, Tian
-
Erkers, Tom
-
Östling, Päivi
-
Bohlin, Anna
-
show more...
-
Österroos, Albin
-
Vesterlund, Matt ...
-
Jafari, Rozbeh
-
Siavelis, Ioanni ...
-
Bäckvall, Helena
-
Kiviluoto, Sante ...
-
Orre, Lukas M.
-
Rantalainen, Mat ...
-
Lehtiö, Janne
-
Lehmann, Sören
-
Kallioniemi, Oll ...
-
Vu, Trung Nghia
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Hematology
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
npj Precision On ...
- By the university
-
Uppsala University
-
Karolinska Institutet