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Atopic dermatitis and chronic kidney disease : a bidirectional Mendelian randomization study
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- Zhang, Han (författare)
- Zhengzhou Univ, Henan Prov Peoples Hosp, Zhengzhou, Peoples R China.;Zhengzhou Univ, Coll Publ Hlth, Zhengzhou, Peoples R China.
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- Yuan, Shuai (författare)
- Karolinska Institutet
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- Li, Yong (författare)
- Univ Freiburg, Inst Genet Epidemiol Epidemiol & Med Bioinformat, Fac Med, Dept Biometry, Freiburg, Germany.;Univ Freiburg, Med Ctr, Freiburg, Germany.
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- Karolinska Institutet Zhengzhou Univ, Henan Prov Peoples Hosp, Zhengzhou, Peoples R China;Zhengzhou Univ, Coll Publ Hlth, Zhengzhou, Peoples R China. (creator_code:org_t)
- Frontiers Media SA, 2023
- 2023
- Engelska.
- Ingår i: Frontiers in Medicine. - : Frontiers Media SA. - 2296-858X. ; 10
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Background: A bidirectional association between atopic dermatitis and chronic kidney disease (CKD) has been revealed in observational studies, whereas the causality of this association was unclear. We conducted a Mendelian randomization study to determine the bidirectional causal association between atopic dermatitis and CKD.Methods: Independent genetic instruments associated with atopic dermatitis and CKD at the genome-wide significance level were chosen from corresponding meta-analyses of genome-wide association studies. Summary-level data for atopic dermatitis were obtained from the EAGLE Eczema consortium (30,047 cases and 40,835 controls) and FinnGen consortium (7,024 cases and 198,740 controls). Summary-level data for CKD were derived from CKDGen consortium (64,164 cases and 625,219 controls) and FinnGen consortium (3,902 cases and 212,841 controls). The inverse-variance weighted method was used in the main analysis and supplemented with three sensitivity analyses.Results: Genetic predisposition to atopic dermatitis was associated with an increased risk of CKD. For a one-unit increase in the prevalence of atopic dermatitis, the odds ratio of CKD was 1.07 (95% confidence interval: 1.01-1.12). In the reverse Mendelian randomization analysis, the odds ratio of atopic dermatitis was 1.14 (95% confidence interval: 1.03-1.26) for a one-unit increase in the prevalence of CKD. The associations persisted in sensitivity analyses and no pleiotropy was detected.Conclusion: This Mendelian randomization study suggests a bidirectional positive association between atopic dermatitis and CKD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- atopic dermatitis
- chronic kidney disease
- Mendelian randomization
- MR-PRESSO
- bidirectional Mendelian randomization
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