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Myalgic Encephalomy...
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and fibromyalgia are indistinguishable by their cerebrospinal fluid proteomes
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Schutzer, Steven E. (author)
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Liu, Tao (author)
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Tsai, Chia-Feng (author)
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Petyuk, Vladislav A. (author)
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Schepmoes, Athena A. (author)
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Wang, Yi-Ting (author)
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Weitz, Karl K. (author)
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- Bergquist, Jonas (author)
- Uppsala universitet,Analytisk kemi
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Smith, Richard D. (author)
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Natelson, Benjamin H (author)
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(creator_code:org_t)
- 2022
- 2022
- English.
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In: bioRxiv Neurology. - : Cold Spring Harbor Laboratory Press (CSHL).
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and fibromyalgia have overlapping neurologic symptoms particularly disabling fatigue. This has given rise to the question whether they are distinct central nervous system (CNS) entities or is one an extension of the other. To investigate this, we used unbiased quantitative mass spectrometry-based proteomics to examine the most proximal fluid to the brain, cerebrospinal fluid (CSF). This was to ascertain if the proteome profile of one was the same or different from the other. We examined two separate groups of ME/CFS, one with (n=15) and one without (n=15) fibromyalgia. We quantified a total of 2,083 proteins using immunoaffinity depletion, tandem mass tag isobaric labeling and offline two-dimensional liquid chromatography coupled to tandem mass spectrometry, including 1,789 that were quantified in all the CSF samples. ANOVA analysis did not yield any proteins with an adjusted p-value < 0.05. This supports the notion that ME/CFS and fibromyalgia as currently defined are not distinct entities.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- vet (subject category)
- art (subject category)
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- By the author/editor
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Schutzer, Steven ...
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Liu, Tao
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Tsai, Chia-Feng
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Petyuk, Vladisla ...
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Schepmoes, Athen ...
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Wang, Yi-Ting
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show more...
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Weitz, Karl K.
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Bergquist, Jonas
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Smith, Richard D ...
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Natelson, Benjam ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
- bioRxiv Neurolog ...
- By the university
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Uppsala University