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Eosinophil-derived ...
Eosinophil-derived neurotoxin levels in early childhood and association with preschool asthma - A prospective observational study
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Färdig, Martin (författare)
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Lie, Anine (författare)
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- Borres, Magnus P., 1956- (författare)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa
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Ekenkrantz, Tina (författare)
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Granum, Berit (författare)
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Haugen, Guttorm (författare)
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Jonassen, Christine M (författare)
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- Movérare, Robert (författare)
- Uppsala universitet,Lungmedicin och allergologi,Lung- allergi- och sömnforskning
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Rehbinder, Eva Maria (författare)
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Skjerven, Håvard O (författare)
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Cathrine, Anne (författare)
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Vettukattil, Riyas (författare)
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Lødrup Carlsen, Karin C (författare)
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- Söderhäll, Cilla (författare)
- Karolinska Institutet
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- Nordlund, Björn (författare)
- Karolinska Institutet
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(creator_code:org_t)
- John Wiley & Sons, 2023
- 2023
- Engelska.
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Ingår i: Clinical and Experimental Allergy. - : John Wiley & Sons. - 0954-7894 .- 1365-2222. ; 53:11, s. 1198-1211
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Introduction: Eosinophil-derived neurotoxin (EDN) is related to childhood asthma, while normal values are lacking. We aimed to document serum EDN levels at 1 and 3 years in general and in non-atopic children, and explore if EDN levels differed by sex or were associated with preschool asthma at 3 years.Methods: From the PreventADALL birth cohort, we included 1233 children with EDN analysed using ImmunoCAP at 1 and/or 3 years. Non-atopic children had no history of wheeze, asthma, allergic sensitization or atopic dermatitis. Preschool asthma was defined as having ≥3 episodes of bronchial obstruction between 2 and 3 years, plus doctor diagnosed asthma and/or asthma medication use by 3 years. The upper limit of normal (ULN) of EDN was defined as the 95th percentile. With Youden Index we calculated EDN cut-off levels for risk of preschool asthma.Results: The overall median (ULN) EDN levels were 27.4 (121) μg/L at 1 year (n = 787), and 20.1 (87.8) μg/L at 3 years (n = 857). Non-atopic children had EDN levels of 24.0 (107) μg/L at 1 year (n = 147), and 17.3 (84.6) μg/L at 3 years (n = 173). EDN levels were higher in boys compared to girls; 32.0 (133) versus 24.5 (97.0) μg/L at 1 year, and 20.9 (96.3) versus 19.0 (72.4) μg/L at 3 years. Preschool asthma was observed in 109/892 (12.2%) children. Higher EDN levels at 1 (>26.7 μg/L) and 3 (≥20.5 μg/L) years were associated with preschool asthma; adjusted OR (95% CI) 2.20 (1.09, 4.41) and 4.68 (2.29, 9.55), respectively.Conclusion and Clinical Relevance: We report EDN values in early childhood, demonstrating higher levels at 1 compared to 3 years and in boys compared to girls at both ages. Higher EDN levels at both ages were associated with preschool asthma. However, EDN cut-off levels for preschool asthma were overall lower than the ULN of non-atopic children, limiting translation into clinical practice.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- PreventADALL
- asthma
- child
- eosinophil-derived neurotoxin
- sex
- type 2 inflammation
- wheeze
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Färdig, Martin
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Lie, Anine
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Borres, Magnus P ...
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Ekenkrantz, Tina
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Granum, Berit
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Haugen, Guttorm
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visa fler...
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Jonassen, Christ ...
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Movérare, Robert
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Rehbinder, Eva M ...
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Skjerven, Håvard ...
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Cathrine, Anne
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Vettukattil, Riy ...
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Lødrup Carlsen, ...
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Söderhäll, Cilla
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Nordlund, Björn
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Uppsala universitet
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Karolinska Institutet