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Sedentary lifestyle...
Sedentary lifestyle, physical activity, and gastrointestinal diseases : evidence from mendelian randomization analysis
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- Chen, Jie (author)
- Zhejiang Univ, Sch Publ Hlth, Sch Med, Hangzhou, Zhejiang, Peoples R China.;Zhejiang Univ, Affiliated Hosp 2, Sch Med, Hangzhou, Zhejiang, Peoples R China.;Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, 138 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.
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- Ruan, Xixian (author)
- Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, 138 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.
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- Fu, Tian (author)
- Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, 138 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.
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- Lu, Shiyuan (author)
- Zhejiang Univ Sch Med, Dept Gastroenterol, Sch Med, Affiliated Hosp 2, Hangzhou, Peoples R China.
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- Gill, Dipender (author)
- Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.
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- He, Zixuan (author)
- Naval Med Univ, Mil Med Univ 2, Changhai Hosp, Dept Gastroenterol, Shanghai, Peoples R China.
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- Burgess, Stephen (author)
- Univ Cambridge, MRC Biostat Unit, Cambridge, England.;Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.
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- Giovannucci, Edward L. (author)
- Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
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- Larsson, Susanna C. (author)
- Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden.;Univ Edinburgh, Usher Inst, Ctr Global Hlth Res, Edinburgh, Scotland.
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- Deng, Minzi (author)
- Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, 138 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.;Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha 410013, Hunan, Peoples R China.
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- Yuan, Shuai (author)
- Karolinska Institutet,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden.
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- Li, Xue (author)
- Zhejiang Univ, Sch Publ Hlth, Sch Med, Hangzhou, Zhejiang, Peoples R China.;Zhejiang Univ, Affiliated Hosp 2, Sch Med, Hangzhou, Zhejiang, Peoples R China.;Univ Edinburgh, Usher Inst, Ctr Global Hlth Res, Edinburgh, Scotland.;Zhejiang Univ Sch Med, Sch Publ Hlth, Dept Big Data Hlth Sci, Sch Publ Hlth,Dept Big Data Hlth Sci, Hangzhou, Peoples R China.
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Zhejiang Univ, Sch Publ Hlth, Sch Med, Hangzhou, Zhejiang, Peoples R China;Zhejiang Univ, Affiliated Hosp 2, Sch Med, Hangzhou, Zhejiang, Peoples R China.;Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, 138 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China. Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, 138 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China. (creator_code:org_t)
- Elsevier, 2024
- 2024
- English.
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In: EBioMedicine. - : Elsevier. - 2352-3964. ; 103
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Abstract
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- Background: The causal associations of physical activity and sedentary behavior with the risk of gastrointestinal disease are unclear. We performed a Mendelian randomization analysis to examine these associations.Methods: Genetic instruments associated with leisure screen time (LST, an indicator of a sedentary lifestyle) and moderate-to-vigorous intensity physical activity (MVPA) at the genome-wide significance (P < 5 x 10-8) level were selected from a genome-wide association study. Summary statistics for gastrointestinal diseases were obtained from the UK Biobank study, the FinnGen study, and large consortia. Multivariable MR analyses were conducted for genetically determined LST with adjustment for MVPA and vice versa. We also performed multivariable MR with adjustment for genetically proxied smoking, body mass index (BMI), waist-to-hip ratio, type 2 diabetes, and fasting insulin for both exposures.Findings: Genetically proxied longer LST was associated with an increased risk of gastrointestinal reflux, gastric ulcer, duodenal ulcer, chronic gastritis, irritable bowel syndrome, diverticular disease, Crohn's disease, ulcerative colitis, non-alcoholic fatty liver disease, alcoholic liver disease, cholangitis, cholecystitis, cholelithiasis, acute pancreatitis, chronic pancreatitis, and acute appendicitis. Most associations remained after adjustment for genetic liability to MVPA. Genetic liability to MVPA was associated with decreased risk of gastroesophageal reflux, gastric ulcer, chronic gastritis, irritable bowel syndrome, cholecystitis, cholelithiasis, acute and chronic pancreatitis. The associations attenuated albeit directionally remained after adjusting for genetically predicted LST. Multivariable MR analysis found that BMI and type 2 diabetes mediated the associations of LST and MVPA with several gastrointestinal diseases.Interpretation: The study suggests that a sedentary lifestyle may play a causal role in the development of many gastrointestinal diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- Gastrointestinal diseases
- Leisure screen time
- Mendelian randomization
- Physical activity
- Sedentary lifestyle
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Chen, Jie
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Ruan, Xixian
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Fu, Tian
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Lu, Shiyuan
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Gill, Dipender
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He, Zixuan
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show more...
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Burgess, Stephen
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Giovannucci, Edw ...
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Larsson, Susanna ...
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Deng, Minzi
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Yuan, Shuai
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Li, Xue
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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EBioMedicine
- By the university
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Uppsala University
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Karolinska Institutet