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Enhanced Punishment Responses in Patients With Schizophrenia : An Event-Related Potential Study

Akgül, Özge (author)
Izmir Democracy Univ, Fac Arts & Sci, Dept Psychol, Izmir, Turkiye.
Fide, Ezgi (author)
Dokuz Eylul Univ, Dept Neurosci, Izmir, Turkiye.
Özel, Fatih (author)
Uppsala universitet,Fysiologi och miljötoxikologi
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Alptekin, Köksal (author)
Dokuz Eylul Univ, Dept Neurosci, Izmir, Turkiye.;Dokuz Eylul Univ, Fac Med, Dept Psychiat, Izmir, Turkiye.
Bora, Emre (author)
Dokuz Eylul Univ, Dept Neurosci, Izmir, Turkiye.;Dokuz Eylul Univ, Fac Med, Dept Psychiat, Izmir, Turkiye.
Akdede, Berna Binnur (author)
Dokuz Eylul Univ, Dept Neurosci, Izmir, Turkiye.;Dokuz Eylul Univ, Fac Med, Dept Psychiat, Izmir, Turkiye.
Yener, Görsev (author)
Dokuz Eylul Univ, Brain Dynam Multidisciplinary Res Ctr, Izmir, Turkiye.;Izmir Univ Econ, Fac Med, Dept Neurol, Izmir, Turkiye.;Dokuz Eylul Univ, Izmir Int Biomed & Genome Inst, Izmir, Turkiye.;Izmir Univ Econ, Fac Med, Dept Neurol, TR-35340 Izmir, Turkiye.
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Izmir Democracy Univ, Fac Arts & Sci, Dept Psychol, Izmir, Turkiye Dokuz Eylul Univ, Dept Neurosci, Izmir, Turkiye. (creator_code:org_t)
Sage Publications, 2024
2024
English.
In: Clinical EEG and Neuroscience. - : Sage Publications. - 1550-0594 .- 2169-5202. ; 55:2, s. 219-229
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • It is well known that abnormal reward processing is a characteristic feature of various psychopathologies including schizophrenia. Reduced reward anticipation has been suggested as a core symptom of schizophrenia. The Monetary Incentive Delay Task (MID) is frequently used to detect reward anticipation. The present study aims to evaluate the amplitude and latency of event-related potential (ERP) P300 in patients with schizophrenia (SCH) compared to healthy controls during the MID task. Twenty patients with SCH and 21 demographically matched healthy controls (HC) were included in the study. ERP P300 amplitude and latency values were compared between groups using an MID task in which reward and loss cues were presented. Relations between P300 and clinical facets were investigated in the patient group. SCH group had enhanced mean P300 amplitudes and delayed peak latency in the punishment condition compared with HC. These higher responses were also associated with negative symptoms. SCH group showed altered reward processing as being more sensitive to loss of reward conditions as firstly evidenced by electrophysiological methods, possibly due to abnormality in various systems including social withdrawal, social defeat, and behavioral inhibition system.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Physiology (hsv//eng)

Keyword

schizophrenia
event-related potentials
loss processing
reward processing
P300

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor
Akgül, Özge
Fide, Ezgi
Özel, Fatih
Alptekin, Köksal
Bora, Emre
Akdede, Berna Bi ...
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Yener, Görsev
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Psychiatry
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Neurology
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Physiology
Articles in the publication
Clinical EEG and ...
By the university
Uppsala University

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