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Effect of Aerobic E...
Effect of Aerobic Exercise and Time-Restricted Feeding on Metabolic Markers and Circadian Rhythm in Mice Fed with the High-Fat Diet
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- Raza, Ghulam Shere (författare)
- Univ Oulu, Fac Med, Med Res Ctr, Res Unit Biomed & Internal Med, Aapistie 5, Oulu 90220, Finland.
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- Kaya, Yagmur (författare)
- Istanbul Kent Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-34406 Istanbul, Turkiye.
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- Stenback, Ville (författare)
- Univ Oulu, Fac Med, Med Res Ctr, Res Unit Biomed & Internal Med, Aapistie 5, Oulu 90220, Finland.
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- Sharma, Ravikant (författare)
- Univ Oulu, Fac Med, Med Res Ctr, Res Unit Biomed & Internal Med, Aapistie 5, Oulu 90220, Finland.
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- Sodum, Nalini (författare)
- Univ Oulu, Fac Med, Med Res Ctr, Res Unit Biomed & Internal Med, Aapistie 5, Oulu 90220, Finland.
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- Jagalur Mutt, Shivaprakash (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Science for Life Laboratory, SciLifeLab
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- Gagnon, Dominique D. (författare)
- Univ Jyvaskyla, Fac Sports & Hlth Sci, Seminaarinkatu 15, Jyvaskyla 40014, Finland.;Univ Helsinki Makelankatu, Fac Med, Dept Sports & Exercise Med, Clin Sports & Exercise Med, Helsinki 00550, Finland.
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- Tulppo, Mikko (författare)
- Univ Oulu, Fac Med, Med Res Ctr, Res Unit Biomed & Internal Med, Aapistie 5, Oulu 90220, Finland.
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- Jarvelin, Marjo-Riitta (författare)
- Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London SW72AZ, England.
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- Herzig, Karl-Heinz (författare)
- Univ Oulu, Fac Med, Med Res Ctr, Res Unit Biomed & Internal Med, Aapistie 5, Oulu 90220, Finland.;Poznan Univ Med Sci, Pediat Inst, Pediat Gastroenterol & Metab Dis, PL-60572 Poznan, Poland.
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- Makela, Kari A. (författare)
- Univ Oulu, Fac Med, Med Res Ctr, Res Unit Biomed & Internal Med, Aapistie 5, Oulu 90220, Finland.
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Univ Oulu, Fac Med, Med Res Ctr, Res Unit Biomed & Internal Med, Aapistie 5, Oulu 90220, Finland Istanbul Kent Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-34406 Istanbul, Turkiye. (creator_code:org_t)
- John Wiley & Sons, 2024
- 2024
- Engelska.
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Ingår i: Molecular Nutrition & Food Research. - : John Wiley & Sons. - 1613-4125 .- 1613-4133. ; 68:5
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Scope: Diet and exercise are significant players in obesity and metabolic diseases. Time-restricted feeding (tRF) has been shown to improve metabolic responses by regulating circadian clocks but whether it acts synergically with exercise remains unknown. It is hypothesized that forced exercise alone or combined with tRF alleviates obesity and its metabolic complications.Methods and resultsMale C57bl6 mice are fed with high-fat or a control diet for 12 weeks either ad libitum or tRF for 10 h during their active period. High-fat diet (HFD)-fed mice are divided into exercise (treadmill for 1 h at 12 m min(-1) alternate days for 9 weeks and 16 m min(-1) daily for the following 3 weeks) and non-exercise groups. tRF and tRF-Ex significantly decreased body weight, food intake, and plasma lipids, and improved glucose tolerance. However, exercise reduced only body weight and plasma lipids. tRF and tRF-Ex significantly downregulated Fasn, Hmgcr, and Srebp1c, while exercise only Hmgcr. HFD feeding disrupted clock genes, but exercise, tRF, and tRF-Ex coordinated the circadian clock genes Bmal1, Per2, and Rev-Erb alpha in the liver, adipose tissue, and skeletal muscles. Conclusion: HFD feeding disrupted clock genes in the peripheral organs while exercise, tRF, and their combination restored clock genes and improved metabolic consequences induced by high-fat diet feeding.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- circadian clocks
- exercise
- metabolic regulations
- obesity
- time-restricted feeding
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Raza, Ghulam She ...
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Kaya, Yagmur
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Stenback, Ville
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Sharma, Ravikant
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Sodum, Nalini
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Jagalur Mutt, Sh ...
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visa fler...
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Gagnon, Dominiqu ...
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Tulppo, Mikko
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Jarvelin, Marjo- ...
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Herzig, Karl-Hei ...
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Makela, Kari A.
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Fysiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Endokrinologi oc ...
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Molecular Nutrit ...
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Uppsala universitet