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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03322naa a2200433 4500 | |
| 001 | oai:DiVA.org:uu-65047 | |
| 003 | SwePub | |
| 008 | 081017s2003 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-650472 URI |
| 024 | 7 | a https://doi.org/10.1034/j.1399-6576.2003.00189.x2 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Liu, X. L.u Uppsala universitet,Institutionen för kirurgiska vetenskaper,Anaesthesiology and Intensive Care4 aut |
| 245 | 1 0 | a Differences in cerebral reperfusion and oxidative injury after cardiac arrest in pigs |
| 264 | c 2003-08-11 | |
| 264 | 1 | b Wiley,c 2003 |
| 338 | a print2 rdacarrier | |
| 520 | a BACKGROUND: An investigation of the free radical scavenger sodium 2-sulfophenyl-N-tert-butyl nitrone (S-PBN) and the weak vasodilatator Tris buffer mixture (TBM) on cerebral cortical blood flow (CCBF) and the jugular bulb concentration of two eicosanoids, indicators of oxidative stress and inflammation, was undertaken in 30 anaesthetized piglets during cardiopulmonary resuscitation (CPR) and after restoration of spontaneous circulation (ROSC).METHODS: Thirty animals were subjected to 8 min of untreated circulatory arrest followed by 8 min of closed-chest CPR. During CPR, the animals were randomized to receive 60 mg/kg S-PBN, 1 mmol/kg TBM or 2 ml/kg normal saline (n = 10 in each group). Systemic haemodynamic variables, CCBF and jugular bulb plasma concentrations of 8-iso-PGF2alpha and 15-keto-dihydro-PGF2alpha were measured.RESULTS: The CCBF during reperfusion after ROSC was greater in the TBM group than in the S-PBN group, the regression coefficient between CCBF and mean arterial blood pressure being lower in the S-PBN group than in the TBM group. The jugular bulb plasma concentration of 8-iso-PGF2alpha during the first 30 min after ROSC was greater in the TBM group than in the S-PBN group. Administration of TBM after vasopressin did not attenuate the pressor effect of vasopressin.CONCLUSION: Administration of S-PBN during CPR results in less cerebral oxidative stress, possibly by promoting normal distribution of cerebral blood flow. | |
| 653 | a CPR | |
| 653 | a reperfusion injury | |
| 653 | a oxidative damage | |
| 653 | a free radical | |
| 653 | a S-PBN | |
| 653 | a cerebral haemodynamics | |
| 653 | a vasopressin | |
| 653 | a buffer | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Wiklund, Larsu Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)larswikl |
| 700 | 1 | a Nozari, A.u Uppsala universitet,Institutionen för kirurgiska vetenskaper,Anaesthesiology and Intensive Care4 aut |
| 700 | 1 | a Rubertsson, Stenu Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)stenrube |
| 700 | 1 | a Basu, Samaru Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Clinical Nutrition4 aut |
| 710 | 2 | a Uppsala universitetb Institutionen för kirurgiska vetenskaper4 org |
| 773 | 0 | t Acta Anaesthesiologica Scandinavicad : Wileyg 47:8, s. 958-967q 47:8<958-967x 0001-5172x 1399-6576 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-65047 |
| 856 | 4 8 | u https://doi.org/10.1034/j.1399-6576.2003.00189.x |
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