id:"swepub:oai:DiVA.org:uu-6509"
Search: id:"swepub:oai:DiVA.org:uu-6509" > Identification and ...
- 1 of 1
- Previous record
- Next record
- To hitlist
Identification and Characterization of Biomarkers in Bacterial Infections
-
- Storm, Martin, 1975- (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
- Engstrand, Lars (thesis advisor)
- Syvänen, Ann-Christine (thesis advisor)
- show more...
- show less...
- (creator_code:org_t)
- ISBN 9155464750
- Uppsala : Acta Universitatis Upsaliensis, 2006
- English 55 s.
- Series: Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 1651-6206 ; 112
- Doctoral thesis (other academic/artistic)
Abstract
Subject headings
Close
- In recent years molecular biology has become an integral part of the clinical laboratory. With an ever increasing number of methodologies and applications being presented each year it has increased our knowledge of how bacteria cause disease as well as our ability to predict disease outcome. The main focus of this thesis has been to develop methods for identifying biomarkers and prediction methods for bacterial infectious diseases by taking advantage of the ever increasing possibilities of molecular biology. We applied cutting edge techniques in order to establish novel platforms for identifying and characterizing biomarkers of disease. In paper one we describe a novel approach to measure levels of antibiotic resistance and viability of C. trachomatis, a method that is a clear improvement over existing techniques. In the second paper we describe the development of two assays designed to type pertussis toxin subunit 1 in circulating strains, in order to facilitate multi center studies for vaccine escape surveillance. In paper three we develop a novel microarray application designed to identify a large number of bacterial traits of H. pylori simultaneously with human genetic polymorphisms in order to identify a collection of risk factors that could be used as a prediction tool for gastric cancer risk. In the last paper we define the “antigenome” of H. pylori and identified 14 promising, previously unreported antigens as well as a number of potential biomarkers.The platform technologies described in this collection of papers will hopefully help us identifying novel ways of fighting and predicting bacterial disease in future studies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Microbiology
- Microbiology
- Bacteriology
- Chlamydia trachomatis
- Bordetella perussis
- Helicobacter pylori
- Real-Time PCR
- Microarray
- Antigenome
- Vaccine
- Biomarker
- Mikrobiologi
- Microbiology, immunology, infectious diseases
- Mikrobiologi, immunologi, infektionssjukdomar
Publication and Content Type
- vet (subject category)
- dok (subject category)
Find in a library
- Identification and Characterization of Biomarkers in Bacterial Infections (Search the publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Storm, Martin, 1 ...
- Engstrand, Lars
- Syvänen, Ann-Chr ...
- Monstein, Hans-J ...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Microbiology in ...
- Parts in the series
- Digital Comprehe ...
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
