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Transforming growth...
Transforming growth factor beta1 genotype and change in left ventricular mass during antihypertensive treatment : results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA)
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- Hallberg, Pär (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Osteoporos,Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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- Lind, Lars (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Department of Medical Sciences, Uppsala University, Uppsala, Sweden; AstraZeneca Research & Development, Mölndal, Sweden
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- Billberger, Katarina (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Osteoporos,Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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- Michaëlsson, Karl (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Orthopaedics,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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- Karlsson, Julia (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Osteoporos,Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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- Kurland, Lisa, 1960- (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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- Kahan, Thomas (author)
- Karolinska Institutet
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- Malmqvist, Karin (author)
- Karolinska Institutet
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- Öhman, K. Peter (author)
- AstraZeneca Research & Development, Mölndal, Sweden; Department of Medicine and Care, Faculty of Health Sciences, Linköping, Sweden
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- Nyström, Fredrik, 1963- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Internmedicin,Endokrin- och magtarmmedicinska kliniken US
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- Liljedahl, Ulrika (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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- Syvänen, Ann-Christne (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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- Melhus, Håkan (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Osteoporos,Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- 2006-12-05
- 2004
- English.
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In: Clinical Cardiology. - : Wiley. - 0160-9289 .- 1932-8737. ; 27:3, s. 169-73
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Abstract
Subject headings
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- BACKGROUND: Angiotensin II, via the angiotensin II type 1 (AT1) receptor, may mediate myocardial fibrosis and myocyte hypertrophy seen in hypertensive left ventricular (LV) hypertrophy through production of transforming growth factor beta1 (TGF-beta1); AT1-receptor antagonists reverse these changes. The TGF-beta1 G + 915C polymorphism is associated with interindividual variation in TGF-beta1 production. No study has yet determined the impact of this polymorphism on the response to antihypertensive treatment. HYPOTHESIS: We aimed to determine whether the TGF-beta1 G + 915C polymorphism was related to change in LV mass during antihypertensive treatment with either an AT1-receptor antagonists or a beta1-adrenoceptor blocker. The polymorphism was hypothesized to have an impact mainly on the irbesartan group. METHODS: We determined the association between the TGF-beta1 genotype and regression of LV mass in 90 patients with essential hypertension and echocardiographically diagnosed LV hypertrophy, randomized in a double-blind study to receive treatment for 48 weeks with either the AT1-receptor antagonist irbesartan or the beta1-adrenoceptor blocker atenolol. RESULTS: Irbesartan-treated patients who were carriers of the C-allele, which is associated with low expression of TGF-beta1, responded with a markedly greater decrease in LV mass index (LVMI) than subjects with the G/G genotype (adjusted mean change in LVMI -44.7 g/m2 vs. -22.2 g/m2, p = 0.007), independent of blood pressure reduction. No association between genotype and change in LVMI was observed in the atenolol group. CONCLUSIONS: The TGF-beta1 G + 915C polymorphism is related to the change in LVMI in response to antihypertensive treatment with the AT1-receptor antagonist irbesartan.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Antihypertensive Agents/*therapeutic use
- Atenolol/therapeutic use
- Biphenyl Compounds/*therapeutic use
- Double-Blind Method
- Female
- Genotype
- Humans
- Hypertension/complications/*drug therapy
- Hypertrophy; Left Ventricular/complications/*drug therapy/physiopathology
- Linear Models
- Male
- Polymorphism; Genetic
- Research Support; Non-U.S. Gov't
- Sweden
- Tetrazoles/*therapeutic use
- Transforming
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hallberg, Pär
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Lind, Lars
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Billberger, Kata ...
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Michaëlsson, Kar ...
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Karlsson, Julia
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Kurland, Lisa, 1 ...
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Kahan, Thomas
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Malmqvist, Karin
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Öhman, K. Peter
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Nyström, Fredrik ...
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Liljedahl, Ulrik ...
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Syvänen, Ann-Chr ...
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Melhus, Håkan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Clinical Cardiol ...
- By the university
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Uppsala University
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Örebro University
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Karolinska Institutet
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Linköping University