id:"swepub:oai:DiVA.org:uu-73052"
Search: id:"swepub:oai:DiVA.org:uu-73052" > Endothelium-depende...
- 1 of 1
- Previous record
- Next record
- To hitlist
Endothelium-dependent vasodilation is related to the fatty acid composition of serum lipids in healthy subjects
-
- Sarabi, Mahziar (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin
-
- Vessby, Bengt (author)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap
-
- Millgård, Jonas (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin
- show more...
- show less...
- (creator_code:org_t)
- 2001
- 2001
- English.
- In: Atherosclerosis. - 0021-9150 .- 1879-1484. ; 156:2, s. 349-355
- Journal article (other academic/artistic)
Abstract
Subject headings
Close
- The fatty acid (FA) composition of the serum lipids has been associated with cardiovascular disease (CVD). As an attenuated endothelium-dependent vasodilation (EDV) has been suggested as an early marker of atherosclerosis, we investigated the relationships between the proportion of FA in serum lipids (cholesterol esters and phospholipids) together with the levels of serum LDL- and HDL-cholesterol and triglycerides and EDV, as well as endothelium-independent vasodilation (EIDV). Fifty-six healthy subjects (31 men and 25 women), aged between 20 and 69 years, underwent measurements of forearm blood flow (FBF) at rest and during local infusion of 2 and 4 microg/min of metacholine (Mch, evaluating EDV), 5 and 10 microg/min of sodium nitroprusside (SNP, evaluating endothelium-independent vasodilation, EIDV) using venous occlusion plethysmography. An index of endothelial function was calculated as the ratio between EDV and EIDV. The proportion of palmitic (16:0) and palmitoleic (16:1) acids were inversely related (r=-0.35 and -0.35, P<0.01 for both), while linoleic acid (18:2 n6) and the HDL-cholesterol concentration were positively related (r=0.35 and 0.36, P<0.01 for both) to the endothelial function index. In multiple regression analysis also including age and gender, palmitoleic acid and HDL-cholesterol were significant independent predictors of endothelial function. Alfa-linolenic acid (18:3 n3) was positively correlated to both EDV and EIDV (r=0.40 and 0.43, P<0.01 for both), indicating a protective effect of this essential FA on vasodilation in general. It is concluded that the FA composition of serum lipids, partly reflecting the composition of dietary fat and previously associated with the development of CVD, was associated with endothelial function in apparently healthy subjects.
Keyword
- Adult
- Aged
- Blood Flow Velocity
- Cross-Sectional Studies
- Dose-Response Relationship; Drug
- Endothelium; Vascular/drug effects/*metabolism
- Fatty Acids/*blood
- Female
- Humans
- Infusions; Intravenous
- Linear Models
- Lipoproteins; HDL Cholesterol/*blood
- Lipoproteins; LDL Cholesterol/*blood
- Male
- Methacholine Chloride/administration & dosage
- Middle Aged
- Nitroprusside/administration & dosage
- Plethysmography
- Radioimmunoassay
- Reference Values
- Regression Analysis
- Sensitivity and Specificity
- Vasodilation/*drug effects/*physiology
- Vasodilator Agents/*administration & dosage
- MEDICINE
- MEDICIN
Publication and Content Type
- vet (subject category)
- art (subject category)
Find in a library
- Atherosclerosis (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Sarabi, Mahziar
- Vessby, Bengt
- Millgård, Jonas
- Lind, Lars
- Articles in the publication
- Atherosclerosis
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
