Effects of blockade of alpha- and beta-adrenoceptors and neuropeptide Y(1) receptors, as well as brachial plexus blockade, on endothelium-dependent vasodilation in the human forearm

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Fältnamn	Indikatorer	Metadata
000		04173naa a2200553 4500
001		oai:DiVA.org:uu-73212
003		SwePub
008		070314s2002 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-732122 URI
024	7	a https://doi.org/10.1046/j.1440-1681.2002.03695.x2 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Johansson, Kristinau Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin4 aut
245	1 0	a Effects of blockade of alpha- and beta-adrenoceptors and neuropeptide Y(1) receptors, as well as brachial plexus blockade, on endothelium-dependent vasodilation in the human forearm
264	1	b Wiley,c 2002
338		a print2 rdacarrier
520		a 1. The aim of the present study was to investigate the effects of alpha-adrenoceptor blockade (phentolamine), beta-adrenoceptor blockade (propranolol), neuropeptide Y(1) receptor blockade and neurogenic blockade (brachial plexus) on endothelium-dependent vasodilation (EDV) in the human forearm. 2. Forty-four young healthy volunteers underwent forearm blood flow (FBF) measurements, using venous occlusion plethysmography, during local intra-arterial infusions of methacholine (MCh; inducing EDV) and sodium nitroprusside (SNP; inducing endothelium-independent vasodilation (EIDV)). These measurements were undertaken at baseline and were repeated with either concomitant local intra-arterial infusion of phentolamine (n = 8), propranolol (n = 7) or saline (n = 6) in the forearm, neuropeptide Y(1) receptor blockade (n = 12) given i.v. or during axillary plexus blockade (n = 11). 3. Both alpha-adrenoceptor blockade and neurogenic blockade induced an upward shift in the dose-response curve for both EDV and EIDV. beta-Adrenoceptor blockade did not change resting FBF or EIDV, but induced a significant decrease in EDV (P = 0.015). Neuropeptide Y(1) receptor blocker induced no significant changes in resting FBF, EDV and EIDV and neither did saline. No changes in blood pressure or heart rate were induced by any of the blockades. 4. Whereas beta-adrenoceptor blockade impaired EDV, alpha-adrenoceptor blockade and neurogenic blockade caused a general vasodilation that was not endothelium dependent. Neuropeptide Y does not seem to influence blood flow in the resting forearm.
653		a Adrenergic alpha-Antagonists/pharmacology
653		a Adrenergic beta-Antagonists/pharmacology
653		a Adult
653		a Brachial Plexus
653		a Endothelium; Vascular/*physiology
653		a Female
653		a Forearm/*blood supply
653		a Humans
653		a Male
653		a Nerve Block
653		a Neuropeptide Y/pharmacology
653		a Receptors; Adrenergic/*metabolism
653		a Receptors; Adrenergic; alpha/metabolism
653		a Receptors; Adrenergic; beta/metabolism
653		a Receptors; Neuropeptide Y/*antagonists & inhibitors
653		a Regional Blood Flow/drug effects
653		a Research Support; Non-U.S. Gov't
653		a Vasodilation/*drug effects
653		a MEDICINE
653		a MEDICIN
700	1	a Eriksson, Matsu Uppsala universitet,Institutionen för kirurgiska vetenskaper,Anaesthesiology and Intensive Care4 aut0 (Swepub:uu)matserik
700	1	a Wahlqvist, Inger4 aut
700	1	a von zur Mühlen, Bengtu Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin4 aut
700	1	a Lind, Larsu Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin4 aut0 (Swepub:uu)larslind
710	2	a Uppsala universitetb Institutionen för medicinska vetenskaper4 org
773	0	t Clinical and experimental pharmacology & physiologyd : Wileyg 29:7, s. 603-607q 29:7<603-607x 0305-1870x 1440-1681
856	4	u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=12060104&dopt=Citation
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-73212
856	4 8	u https://doi.org/10.1046/j.1440-1681.2002.03695.x

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Av lärosätet: Uppsala universitet

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