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The complete genome...
The complete genome sequence of Francisella tularensis, the causative agent of tularemia
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- Larsson, Pär (author)
- Umeå universitet,Klinisk bakteriologi
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Oyston, Petra (author)
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Chain, Patrick (author)
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Chu, May (author)
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Duffield, Melanie (author)
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- Fuxelius, Hans-Henrik (author)
- Uppsala universitet,Molekylär evolution
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Garcia, Emilio (author)
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- Hälltorp, Greger (author)
- Uppsala universitet,Molekylär evolution
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Johansson, Daniel (author)
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Isherwood, Karen (author)
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Karp, Peter (author)
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Larsson, Eva (author)
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Liu, Ying (author)
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Mitchell, Stephen (author)
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Prior, Joann (author)
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Prior, Richard (author)
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Malfatti, Stephanie (author)
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- Sjöstedt, Anders (author)
- Umeå universitet,Klinisk bakteriologi
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- Svensson, Kerstin (author)
- Umeå universitet,Infektionssjukdomar
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Thompson, Nick (author)
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Vergez, Lisa (author)
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Wagg, Jonathan (author)
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Wren, Brendan (author)
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Lindler, Luther (author)
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- Andersson, Siv (author)
- Uppsala universitet,Molekylär evolution
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- Forsman, Mats (author)
- FOI, Umeå, Sweden
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Titball, Richard (author)
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Fuxelius, Hans-Erik (author)
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(creator_code:org_t)
- 2005-01-09
- 2005
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 37:2, s. 153-159
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Francisella tularensis is one of the most infectious human pathogens known. In the past, both the former Soviet Union and the US had programs to develop weapons containing the bacterium. We report the complete genome sequence of a highly virulent isolate of F. tularensis (1,892,819 bp). The sequence uncovers previously uncharacterized genes encoding type IV pili, a surface polysaccharide and iron-acquisition systems. Several virulence-associated genes were located in a putative pathogenicity island, which was duplicated in the genome. More than 10% of the putative coding sequences contained insertion-deletion or substitution mutations and seemed to be deteriorating. The genome is rich in IS elements, including IS630 Tc-1 mariner family transposons, which are not expected in a prokaryote. We used a computational method for predicting metabolic pathways and found an unexpectedly high proportion of disrupted pathways, explaining the fastidious nutritional requirements of the bacterium. The loss of biosynthetic pathways indicates that F. tularensis is an obligate host-dependent bacterium in its natural life cycle. Our results have implications for our understanding of how highly virulent human pathogens evolve and will expedite strategies to combat them.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- Molecular biology
- Molekylärbiologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Larsson, Pär
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Oyston, Petra
-
Chain, Patrick
-
Chu, May
-
Duffield, Melani ...
-
Fuxelius, Hans-H ...
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show more...
-
Garcia, Emilio
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Hälltorp, Greger
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Johansson, Danie ...
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Isherwood, Karen
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Karp, Peter
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Larsson, Eva
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Liu, Ying
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Mitchell, Stephe ...
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Prior, Joann
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Prior, Richard
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Malfatti, Stepha ...
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Sjöstedt, Anders
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Svensson, Kersti ...
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Thompson, Nick
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Vergez, Lisa
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Wagg, Jonathan
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Wren, Brendan
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Lindler, Luther
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Andersson, Siv
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Forsman, Mats
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Titball, Richard
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Fuxelius, Hans-E ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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Nature Genetics
- By the university
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Uppsala University
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Umeå University