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Sökning: id:"swepub:oai:DiVA.org:uu-79630" > Family history of h...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005227naa a2200781 4500
001oai:DiVA.org:uu-79630
003SwePub
008060629s2005 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-15217
009oai:prod.swepub.kib.ki.se:1935567
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-796302 URI
0247 a https://doi.org/10.1093/jnci/dji2932 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-152172 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:19355672 URI
040 a (SwePub)uud (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a vet2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Chang, Ellen T.4 aut
2451 0a Family history of hematopoietic malignancy and risk of lymphoma
264 c 2005-10-05
264 1b Oxford University Press (OUP),c 2005
338 a print2 rdacarrier
520 a BACKGROUND: A family history of hematopoietic malignancy is associated with an increased risk of non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL), although the magnitude of the relative risk is unclear. We estimated the association between familial hematopoietic cancer and risk of lymphoma using validated, registry-based family data, and we also investigated whether associations between some environmental exposures and risk of lymphoma vary between individuals with and without such a family history. METHODS: In a population-based case-control study of malignant lymphoma, 1506 case patients and 1229 control subjects were linked to the Swedish Multi-Generation Register and then to the Swedish Cancer Register to ascertain history of cancer in first-degree relatives of patients with malignant lymphoma. Multiple logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for associations with the risk of lymphoma. RESULTS: A history of hematopoietic malignancy in any first-degree relative was associated with an increased risk of all NHL (OR = 1.8, 95% CI = 1.2 to 2.5), common B-cell NHL subtypes, and HL. Relative risks were generally stronger in association with sibling hematopoietic cancer (OR for all NHL = 3.2, 95% CI = 1.3 to 7.6) than with parental hematopoietic cancer (OR = 1.6, 95% CI = 1.1 to 2.3). A family history of NHL or chronic lymphocytic leukemia (CLL) was associated with an increased risk of several NHL subtypes and HL, whereas familial multiple myeloma was associated with a higher risk of follicular lymphoma. There was no statistically significant heterogeneity in NHL risk associations with environmental factors between individuals with and without familial hematopoietic malignancy. CONCLUSIONS: The increased risk of NHL and HL among individuals with a family history of hematopoietic malignancy was approximately twofold for both lymphoma types. There was no evidence that etiologic associations varied between familial NHL and nonfamilial NHL.
653 a Adult
653 a Aged
653 a Case-Control Studies
653 a Confidence Intervals
653 a Environmental Exposure/adverse effects
653 a Female
653 a Genetic Predisposition to Disease
653 a Hematologic Neoplasms/*genetics
653 a Hodgkin Disease/*epidemiology/etiology/*genetics
653 a Humans
653 a Incidence
653 a Leukemia; Lymphocytic; Chronic/genetics
653 a Logistic Models
653 a Lymphoma; Follicular/genetics
653 a Lymphoma; Non-Hodgkin/*epidemiology/etiology/*genetics
653 a Male
653 a Medical Record Linkage
653 a Middle Aged
653 a Multiple Myeloma/genetics
653 a Odds Ratio
653 a Registries
653 a Research Support; N.I.H.; Extramural
653 a Research Support; Non-U.S. Gov't
653 a Research Support; U.S. Gov't; P.H.S.
653 a Risk Assessment
653 a Risk Factors
653 a Sweden/epidemiology
653 a MEDICINE
653 a MEDICIN
7001 a Ekström Smedby, Karinu Karolinska Institutet4 aut
7001 a Hjalgrim, Henriku Karolinska Institutet4 aut
7001 a Porwit-MacDonald, Annau Karolinska Institutet4 aut
7001 a Roos, Göranu Umeå universitet,Patologi4 aut0 (Swepub:umu)goro0001
7001 a Glimelius, Bengtu Karolinska Institutet,Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi4 aut0 (Swepub:uu)bengglim
7001 a Adami, Hans-Olov4 aut
7102 a Karolinska Institutetb Patologi4 org
7730 t Journal of the National Cancer Instituted : Oxford University Press (OUP)g 97:19, s. 1466-1474q 97:19<1466-1474x 0027-8874x 1460-2105
8564 u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=16204696&dopt=Citation
8564 u https://academic.oup.com/jnci/article-pdf/97/19/1466/7686630/dji293.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-79630
8564 8u https://doi.org/10.1093/jnci/dji293
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-15217
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:1935567

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