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The influence of PV...
The influence of PVP incorporation on moisture-induced surface crystallization of amorphous spray-dried lactose particles
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- Mahlin, Denny (author)
- Uppsala universitet,Institutionen för farmaci,Uppsala University
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- Berggren, Jonas (author)
- Uppsala universitet,Institutionen för farmaci,Uppsala University
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- Gelius, Ulrik (author)
- Uppsala universitet,Fysiska institutionen,Uppsala University
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- Engström, Sven, 1951 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Alderborn, Göran (author)
- Uppsala universitet,Institutionen för farmaci,Uppsala University
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(creator_code:org_t)
- Elsevier BV, 2006
- 2006
- English.
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In: International Journal of Pharmaceutics. - : Elsevier BV. - 0378-5173 .- 1873-3476. ; 321:1-2, s. 78-85
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We have recently shown that atomic force microscopy (AFM) may be an appropriate method for characterisation of the re-crystallization of amorphous particles. In this study, spray-dried composite particles consisting of lactose and polyvinyl pyrrolidon (PVP) were characterised by AFM and electron spectroscopy for chemical analysis (ESCA), and their response on increasing the relative humidity (RH) was investigated. The PVP content in the particles used was 0, 5 or 25 wt.% of either PVP K 17 or PVP K90. All composite particles were found to be enriched with PVP at the surface. The incorporation of PVP in the particles influenced the way the particles responded to an increase in RH. The specific RH interval in which the surface of the particles smoothened and the RH where crystallization could be detected, increased with an increase in the amount and molecular weight of the PVP in the particles. The crystallization kinetics of single particles was analysed with AFM and by utilising the JMAK equation. The rate constant for this transformation increased in an exponential manner with increasing RH. Furthermore, above the RH needed for the crystallization to occur, the exponential increase in the crystallization rate was larger for particles with higher polymer content which indicates that the stabilising effect decreases as the water content in the particles becomes higher. In this study we report a method for determination of crystallization kinetics on single composite particles, which is valuable when evaluating the effect of stabilisers in amorphous powders.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- lactose
- atomic force microscopy
- crystallization
- rate constant
- spray-dried particles
- electron spectroscopy for chemical analysis
- PHARMACY
- FARMACI
Publication and Content Type
- ref (subject category)
- art (subject category)
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