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Fondue and transglutaminase in the Drosophila larval clot
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- Lindgren, Malin (author)
- Södertörns högskola,Institutionen för livsvetenskaper
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- Riazi, Raha (author)
- Stockholms universitet
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- Lesch, Christine (author)
- Stockholms universitet
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- (creator_code:org_t)
- Elsevier BV, 2008
- 2008
- English.
- In: Journal of insect physiology. - : Elsevier BV. - 0022-1910 .- 1879-1611. ; 54:3, s. 586-592
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Hemolymph coagulation is vital for larval hemostasis and important in immunity, yet the molecular basis of coagulation is not well understood in insects. Of the larval clotting factors identified in Drosophila, Fondue is not conserved in other insects, but is notable for its effects on the clot's physical properties, a possible function in the cuticle, and for being a substrate of transglutaminase. Transglutaminase is the only mammalian clotting factor found in Drosophila, and as it acts in coagulation in other invertebrates, it is also likely to be important in clotting in Drosophila. Here we describe a Fondue-GFP fusion construct that labels the cuticle and clot, and show that chemical inhibition and RNAi knockdown of the Drosophila transglutaminase gene affect clot properties and composition in ways similar to knockdown of the fon gene. Thus, Fondue appears to be incorporated into the cuticle and is a key transglutaminase substrate in the clot. This is also the first direct functional confirmation that transglutaminase acts in coagulation in Drosophila.
Subject headings
- NATURVETENSKAP -- Biologi -- Zoologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Zoology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Drosophila
- Fondue
- Transglutaminase
- Coagulation
- Immunity
- Animal physiology
- Zoofysiologi
- Zoophysiology
- Zoofysiologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- NATURAL SCIENCES
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