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Evidence for turnov...
Evidence for turnover of functional noncoding DNA in mammalian genome evolution
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- Smith, Nick G.C. (författare)
- Uppsala universitet,Evolutionsbiologi
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- Brandström, Mikael (författare)
- Uppsala universitet,Evolutionsbiologi
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- Ellegren, Hans (författare)
- Uppsala universitet,Evolutionsbiologi
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(creator_code:org_t)
- Elsevier BV, 2004
- 2004
- Engelska.
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Ingår i: Genomics. - : Elsevier BV. - 0888-7543 .- 1089-8646. ; 84:5, s. 806-813
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The vast majority of the mammalian genome does not code for proteins, and a fundamental question in genomics is: What proportion of the noncoding mammalian genome is functional? Most attempts to address this issue use sequence comparisons between highly diverged mammals such as human and mouse to identify conservation due to negative selection. But such comparisons will underestimate the true proportion of functional noncoding DNA if there is turnover, if patterns of negative selection change over time. Here we test whether the inferred level of negative selection differs between different pairwise species comparisons. Using a multiple alignment of more than a megabase of contiguous sequence from eight mammalian species, we find a strong negative relationship between inferred levels of negative selection and pairwise divergence using 21 pairwise comparisons. This result suggests that there is a high rate of turnover of functional noncoding elements in the mammalian genome, so measures of functional constraint based on human–mouse comparisons may seriously underestimate the true value.
Ämnesord
- NATURVETENSKAP -- Biologi -- Utvecklingsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Developmental Biology (hsv//eng)
Nyckelord
- Mutation-rate variation
- Noncoding conserved blocks
- Negative selection
- Functional ncDNA
- Developmental biology
- Utvecklingsbiologi
- Zoologisk utvecklingsbiologi
- Animal Development
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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