id:"swepub:oai:DiVA.org:uu-89860"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03782naa a2200553 4500 | |
| 001 | oai:DiVA.org:uu-89860 | |
| 003 | SwePub | |
| 008 | 020503s2004 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-898602 URI |
| 024 | 7 | a https://doi.org/10.1080/000155504100355062 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Karlsson, Teresau Uppsala universitet,Dermatologi och venereologi4 aut |
| 245 | 1 0 | a Immunofluorescence localization of nuclear retinoid receptors in psoriasis versus normal human skin |
| 264 | 1 | b Medical Journals Sweden AB,c 2004 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Psoriasis responds favourably to treatment with retinoids but the cellular pathways mediating these effects are poorly understood. Retinoids regulate keratinocyte proliferation and maturation via binding to nuclear retinoic acid receptors (mainly RARalpha and RARgamma) which form heterodimers with the 9-cis-RA receptor, RXRalpha. We have previously shown that mRNA expression of RARalpha and RXRalpha is down-regulated in psoriatic lesions as compared with non-lesional human skin. In the present study, we investigated the protein expression of RARalpha, RARgamma and RXRalpha in normal and psoriatic skin using indirect immunofluorescence analysis. Epidermal keratinocytes of normal and non-lesional psoriatic skin displayed similar nuclear localization of all three receptors; RARalpha was detected with decreasing intensity from basal to suprabasal layers, RARgamma showed the opposite trend, whereas RXRalpha was evenly expressed throughout the epidermis. In lesional psoriatic skin, however, all three receptor proteins showed a much higher staining intensity in the lower half of the epidermis; in particular, RARalpha immunoreactivity was low or even absent in the upper layers of epidermis. The results support the idea that psoriasis is associated with abnormal retinoid signalling in lesional epidermis. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Dermatologi och venereologi0 (SwePub)302042 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dermatology and Venereal Diseases0 (SwePub)302042 hsv//eng |
| 653 | a Adult | |
| 653 | a Aged | |
| 653 | a Aged; 80 and over | |
| 653 | a Female | |
| 653 | a Fluorescent Antibody Technique | |
| 653 | a Humans | |
| 653 | a Keratinocytes | |
| 653 | a Male | |
| 653 | a Middle Aged | |
| 653 | a Psoriasis/*immunology | |
| 653 | a Receptors; Retinoic Acid/immunology | |
| 653 | a Research Support; Non-U.S. Gov't | |
| 653 | a Retinoid X Receptor alpha/immunology | |
| 653 | a Retinoid X Receptors/*immunology | |
| 653 | a Dermatology and venerology | |
| 653 | a Dermatologi och venerologi | |
| 653 | a Dermatology and Venerology | |
| 653 | a Dermatologi och venereologi | |
| 700 | 1 | a Rollman, Olau Uppsala universitet,Dermatologi och venereologi4 aut |
| 700 | 1 | a Vahlquist, Andersu Uppsala universitet,Dermatologi och venereologi4 aut |
| 700 | 1 | a Törmä, Hansu Uppsala universitet,Dermatologi och venereologi4 aut0 (Swepub:uu)hanstorm |
| 710 | 2 | a Uppsala universitetb Dermatologi och venereologi4 org |
| 773 | 0 | t Acta Dermato-Venereologicad : Medical Journals Sweden ABg 84:5, s. 363-369q 84:5<363-369x 0001-5555x 1651-2057 |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:161682/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://www.medicaljournals.se/acta/download/10.1080/00015550410035506/ |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-89860 |
| 856 | 4 8 | u https://doi.org/10.1080/00015550410035506 |
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