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Non-aquoeus capilla...
Non-aquoeus capillary electrophoretic separation of enantiomeric amines with (-)-2,3:4,6-di-O-isopropylidene-2-keto-L-gulonic acid as chiral counter ion
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- Carlsson, Ylva (author)
- Uppsala universitet,Avdelningen för analytisk farmaceutisk kemi
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- Hedeland, Mikael (author)
- Uppsala universitet,Avdelningen för analytisk farmaceutisk kemi
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- Bondesson, Ulf (author)
- Uppsala universitet,Avdelningen för analytisk farmaceutisk kemi
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- Pettersson, Curt (author)
- Uppsala universitet,Avdelningen för analytisk farmaceutisk kemi
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(creator_code:org_t)
- Elsevier, 2001
- 2001
- English.
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In: Journal of Chromatography A. - : Elsevier. - 0021-9673. ; 922:1-2, s. 303-311
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- (2)-2,3:4,6-Di-O-isopropylidene-2-keto-L-gulonic acid [(2)-DIKGA] has been introduced as a chiral counter ion innon-aqueous capillary electrophoresis. High enantioresolutions (R $3) were obtained for amines, e.g., pronethalol, labetalol Sand bambuterol. Methanol containing NaOH and (2)-DIKGA was used as the background electrolyte. The counter ionconcentration and the nature of the injection medium were found to affect the chiral separation. Covalent coating of thefused-silica capillary reduced the electro-osmotic flow resulting in improved enantioresolutions.
Subject headings
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Keyword
- Non-aqueous capillary electrophoresis; Enantiomer separation; Background electrolyte composition; Amines; Diisopropylideneketogulonic acid; Labetalol
- Analytical Pharmaceutical Chemistry
- Analytisk farmaceutisk kemi
Publication and Content Type
- ref (subject category)
- art (subject category)
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