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Non-aquoeus capillary electrophoretic separation of enantiomeric amines with (-)-2,3:4,6-di-O-isopropylidene-2-keto-L-gulonic acid as chiral counter ion

Carlsson, Ylva (author)
Uppsala universitet,Avdelningen för analytisk farmaceutisk kemi
Hedeland, Mikael (author)
Uppsala universitet,Avdelningen för analytisk farmaceutisk kemi
Bondesson, Ulf (author)
Uppsala universitet,Avdelningen för analytisk farmaceutisk kemi
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Pettersson, Curt (author)
Uppsala universitet,Avdelningen för analytisk farmaceutisk kemi
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 (creator_code:org_t)
Elsevier, 2001
2001
English.
In: Journal of Chromatography A. - : Elsevier. - 0021-9673. ; 922:1-2, s. 303-311
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • (2)-2,3:4,6-Di-O-isopropylidene-2-keto-L-gulonic acid [(2)-DIKGA] has been introduced as a chiral counter ion innon-aqueous capillary electrophoresis. High enantioresolutions (R $3) were obtained for amines, e.g., pronethalol, labetalol Sand bambuterol. Methanol containing NaOH and (2)-DIKGA was used as the background electrolyte. The counter ionconcentration and the nature of the injection medium were found to affect the chiral separation. Covalent coating of thefused-silica capillary reduced the electro-osmotic flow resulting in improved enantioresolutions.

Subject headings

NATURVETENSKAP  -- Kemi -- Analytisk kemi (hsv//swe)
NATURAL SCIENCES  -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medicinal Chemistry (hsv//eng)

Keyword

Non-aqueous capillary electrophoresis; Enantiomer separation; Background electrolyte composition; Amines; Diisopropylideneketogulonic acid; Labetalol
Analytical Pharmaceutical Chemistry
Analytisk farmaceutisk kemi

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By the author/editor
Carlsson, Ylva
Hedeland, Mikael
Bondesson, Ulf
Pettersson, Curt
About the subject
NATURAL SCIENCES
NATURAL SCIENCES
and Chemical Science ...
and Analytical Chemi ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medicinal Chemis ...
Articles in the publication
Journal of Chrom ...
By the university
Uppsala University

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