Sökning: id:"swepub:oai:DiVA.org:uu-95063" > Aire deficient mice...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 03602naa a2200445 4500 | |
001 | oai:DiVA.org:uu-95063 | |
003 | SwePub | |
008 | 061110s2006 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:1936572 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-950632 URI |
024 | 7 | a https://doi.org/10.1182/blood-2006-04-0196792 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19365722 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Hässler, Signeu Uppsala universitet,Klinisk bakteriologi,Autoimmuna sjukdomar (Kämpe)4 aut0 (Swepub:uu)sihas676 |
245 | 1 0 | a Aire deficient mice develop hematopoetic irregularities and marginal zone B cell lymphoma |
264 | 1 | b American Society of Hematology,c 2006 |
338 | a print2 rdacarrier | |
520 | a Autoimmune polyendocrine syndrome type I (APS I) is an inherited recessive disorder with a progressive immunological destruction of many tissues including the adrenal cortex, the parathyroid glands, and the gonads. APS I is caused by mutations in the AIRE gene (autoimmune regulator), expressed in cells of the thymus and spleen, suggesting a role in central and peripheral tolerance. Aire(-/-) mice replicate the autoimmune features of APS I patients with the presence of multiple autoantibodies and lymphocytic infiltrates in various tissues, but young mice appear clinically healthy. We here report the investigation of 15- to 24-month-old Aire(-/-) mice. We did not observe any endocrinological abnormalities, nor did sera from these mice recognize known APS I autoantigens. Interestingly, however, there was a high frequency of marginal zone B-cell lymphoma in Aire(-/-) mice and liver infiltrates of B cells, suggesting chronic antigen exposure and exaggerated activation. Furthermore, increased numbers of monocytes in blood were identified as well as augmented numbers of metallophilic macrophages in the spleen. We propose that Aire, in addition to its function in the thymus, also has a peripheral regulatory role by controlling the development of antigen-presenting cells (APCs) and marginal zone B-cell activation. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng |
653 | a Haematology | |
653 | a Hematologi | |
700 | 1 | a Ramsey, Chris4 aut |
700 | 1 | a Karlsson, Mikael C.I.u Karolinska Institutet4 aut |
700 | 1 | a Larsson, Disa4 aut |
700 | 1 | a Herrmann, Björnu Uppsala universitet,Klinisk bakteriologi4 aut0 (Swepub:uu)bjorherr |
700 | 1 | a Rozell, Björnu Karolinska Institutet4 aut |
700 | 1 | a Backheden, Magnusu Karolinska Institutet4 aut |
700 | 1 | a Peltonen, Leena4 aut |
700 | 1 | a Kämpe, Olleu Uppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar (Kämpe)4 aut0 (Swepub:uu)ollekamp |
700 | 1 | a Winqvist, Olau Karolinska Institutet,Uppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar (Kämpe)4 aut0 (Swepub:uu)olawinqv |
710 | 2 | a Uppsala universitetb Klinisk bakteriologi4 org |
773 | 0 | t Bloodd : American Society of Hematologyg 108:6, s. 1941-1948q 108:6<1941-1948x 0006-4971x 1528-0020 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-95063 |
856 | 4 8 | u https://doi.org/10.1182/blood-2006-04-019679 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1936572 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy