Search: id:"swepub:oai:DiVA.org:uu-98245" >
A mutation in hairl...
A mutation in hairless dogs implicates FOXI3 in ectodermal development
-
Drögemüller, Cord (author)
-
Karlsson, Elinor K (author)
-
Hytönen, Marjo K (author)
-
show more...
-
Perloski, Michele (author)
-
Dolf, Gaudenz (author)
-
Sainio, Kirsi (author)
-
Lohi, Hannes (author)
-
- Lindblad-Toh, Kerstin (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
-
Leeb, Tosso (author)
-
show less...
-
(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2008
- 2008
- English.
-
In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 321:5895, s. 1462-
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Mexican and Peruvian hairless dogs and Chinese crested dogs are characterized by missing hair and teeth, a phenotype termed canine ectodermal dysplasia (CED). CED is inherited as a monogenic autosomal semidominant trait. With genomewide association analysis we mapped the CED mutation to a 102-kilo-base pair interval on chromosome 17. The associated interval contains a previously uncharacterized member of the forkhead box transcription factor family (FOXI3), which is specifically expressed in developing hair and teeth. Mutation analysis revealed a frameshift mutation within the FOXI3 coding sequence in hairless dogs. Thus, we have identified FOXI3 as a regulator of ectodermal development.
Keyword
- NATURAL SCIENCES
- NATURVETENSKAP
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Science
(Search for host publication in LIBRIS)
To the university's database