Search: id:"swepub:oai:gup.ub.gu.se/103574" >
The G428A nonsense ...
The G428A nonsense mutation in FUT2 provides strong but not absolute protection against symptomatic GII.4 Norovirus infection. : Novel GII.4 disease pattern
-
- Carlsson, Beatrice (author)
- Linköpings universitet,Molekylär virologi,Hälsouniversitetet
-
- Kindberg, Elin (author)
- Linköpings universitet,Molekylär virologi,Hälsouniversitetet
-
- Buesa, Javier (author)
- University of Valencia
-
show more...
-
- Rydell, Gustaf E (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,Sahlgrenska University Hospital
-
- Lidón, Marta Fos (author)
- University of Valencia
-
- Montava, Rebeca (author)
- University of Valencia
-
- Abu Mallouh, Reem (author)
- University of Valencia
-
- Grahn, Ammi, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,Sahlgrenska University Hospital
-
- Rodríguez-Díaz, Jesús (author)
- University of Valencia
-
- Bellido, Juan (author)
- Centro de Salud Pública
-
- Arnedo, Alberto (author)
- Centro de Salud Pública
-
- Larson, Göran, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,Sahlgrenska University Hospital
-
- Svensson, Lennart (author)
- Linköpings universitet,Molekylär virologi,Hälsouniversitetet
-
show less...
-
(creator_code:org_t)
- 2009-05-18
- 2009
- English.
-
In: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 4:5
- Related links:
-
https://journals.plo...
-
show more...
-
https://liu.diva-por... (primary) (Raw object)
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- In November 2004, 116 individuals in an elderly nursing home in El Grao de Castellón, Spain were symptomatically infected with genogroup II.4 (GII.4) norovirus. The global attack rate was 54.2%. Genotyping of 34 symptomatic individuals regarding the FUT2 gene revealed that one patient was, surprisingly, a non-secretor, hence indicating secretor-independent infection. Lewis genotyping revealed that Lewis-positive and negative individuals were susceptible to symptomatic norovirus infection indicating that Lewis status did not predict susceptibility. Saliva based ELISA assays were used to determine binding of the outbreak virus to saliva samples. Saliva from a secretor-negative individual bound the authentic outbreak GII.4 Valencia/2004/Es virus, but did not in contrast to secretor-positive saliva bind VLP of other strains including the GII.4 Dijon strain. Amino acid comparison of antigenic A and B sites located on the external loops of the P2 domain revealed distinct differences between the Valencia/2004/Es and Dijon strains. All three aa in each antigenic site as well as 10/11 recently identified evolutionary hot spots, were unique in the Valencia/2004/Es strain compared to the Dijon strain. To the best of our knowledge, this is the first example of symptomatic GII.4 norovirus infection of a Le(a+b-) individual homozygous for the G428A nonsense mutation in FUT2. Taken together, our study provides new insights into the host genetic susceptibility to norovirus infections and evolution of the globally dominating GII.4 viruses.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Keyword
- ABO Blood-Group System
- genetics
- Caliciviridae Infections
- genetics
- Codon
- Nonsense
- genetics
- Disease Outbreaks
- Enzyme-Linked Immunosorbent Assay
- Fucosyltransferases
- genetics
- Genotype
- Humans
- Lewis Blood-Group System
- genetics
- Norovirus
- classification
- Phylogeny
- Reverse Transcriptase Polymerase Chain Reaction
- Saliva
- virology
- Spain
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
PloS one
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Carlsson, Beatri ...
-
Kindberg, Elin
-
Buesa, Javier
-
Rydell, Gustaf E
-
Lidón, Marta Fos
-
Montava, Rebeca
-
show more...
-
Abu Mallouh, Ree ...
-
Grahn, Ammi, 196 ...
-
Rodríguez-Díaz, ...
-
Bellido, Juan
-
Arnedo, Alberto
-
Larson, Göran, 1 ...
-
Svensson, Lennar ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Microbiology in ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Infectious Medic ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Other Clinical M ...
- Articles in the publication
-
PloS one
- By the university
-
University of Gothenburg
-
Linköping University