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Glucocorticoid receptor inhibits microtubule assembly in vitro.
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- Akner, Gunnar, 1953- (author)
- Karolinska Institutet,Örebro universitet,Hälsoakademin
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- Wikström, A C (author)
- Karolinska Institutet
- Strömstedt, P E (author)
- show more...
- Stockman, O (author)
- Gustafsson, J A (author)
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- (creator_code:org_t)
- Elsevier BV, 1995
- 1995
- English.
- In: Molecular and cellular endocrinology. - : Elsevier BV. - 0303-7207 .- 1872-8057. ; 110:1-2, s. 49-54
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The effect of glucocorticoid hormones, purified glucocorticoid receptor (GR) and purified heat shock protein M(r) 90,000 (hsp90) on microtubule (MT) assembly in vitro was tested by a spectrophotometric MT assembly assay and electron microscopy. GR significantly prolonged the nucleation phase, slowed down the assembly rate and reduced the maximal amplitude of MT assembly compared with control. The effects were partially reversed by the addition of glucocorticoid hormone. GR associated with MTs. These results indicate that GR affects MT assembly in vitro, which may be a functional correlate to the structural association of GR with MTs. This implies that factors affecting GR may affect MT assembly in vivo.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- Animals
- Blotting
- Western
- Cattle
- HSP90 Heat-Shock Proteins
- physiology
- Kinetics
- Microscopy
- Electron
- Microtubule Proteins
- metabolism
- Microtubules
- metabolism
- ultrastructure
- Rats
- Receptors
- Glucocorticoid
- physiology
- Spectrophotometry
- Cellforskning
Publication and Content Type
- ref (subject category)
- art (subject category)
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- University of Gothenburg
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