id:"swepub:oai:gup.ub.gu.se/119015"
Search: id:"swepub:oai:gup.ub.gu.se/119015" > Stimulation of chol...
- 1 of 1
- Previous record
- Next record
- To hitlist
Stimulation of cholecystokinin-A receptors with GI181771X does not cause weight loss in overweight or obese patients.
- Jordan, J (author)
- Greenway, F L (author)
- Leiter, L A (author)
- show more...
- Li, Z (author)
- Murphy, K (author)
- Hill, J (author)
- Kler, L (author)
- Aftring, R P (author)
- show less...
- (creator_code:org_t)
- 2007-06-27
- 2008
- English.
- In: Clinical pharmacology and therapeutics. - : Springer Science and Business Media LLC. - 1532-6535 .- 0009-9236. ; 83:2, s. 281-7
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Cholecystokinin (CCK) decreases meal size through activation of CCK-A receptors on vagal afferents. We tested the hypothesis that the selective CCK-A agonist GI181771X induces weight loss in obese patients. Patients with body mass index > or = 30 or > or = 27 kg/m2 with concomitant risk factors were randomized to 24-week, double-blind treatment with different GI181771X doses or matching placebo together with a hypocaloric diet. The primary efficacy end point was the absolute change in body weight. To monitor pancreatic and gallbladder effects, patients underwent abdominal ultrasound and magnetic resonance imaging before and after treatment. We randomized 701 patients to double-blind treatment. GI181771X did not reduce body weight and had no effect on waist circumference or other cardiometabolic risk markers. Gastrointestinal side effects were more common with GI181771X than with placebo treatment, whereas hepatobiliary or pancreatic abnormalities did not occur. CCK-A by itself does not have a central role in long-term energy balance.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Adult
- Anti-Obesity Agents
- adverse effects
- therapeutic use
- Benzodiazepines
- adverse effects
- therapeutic use
- Caloric Restriction
- Combined Modality Therapy
- Double-Blind Method
- Female
- Gallbladder
- drug effects
- Humans
- Liver
- drug effects
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Obesity
- diet therapy
- drug therapy
- metabolism
- pathology
- Pancreas
- drug effects
- Receptor
- Cholecystokinin A
- agonists
- metabolism
- Time Factors
- Treatment Outcome
- Ultrasonography
- Weight Loss
- drug effects
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Clinical pharmacology and therapeutics (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Jordan, J
- Greenway, F L
- Leiter, L A
- Li, Z
- Jacobson, Peter, ...
- Murphy, K
- show more...
- Hill, J
- Kler, L
- Aftring, R P
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- Articles in the publication
- Clinical pharmac ...
- By the university
- University of Gothenburg
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
