Sökning: id:"swepub:oai:gup.ub.gu.se/130629" > Vagal sparing surgi...
Fältnamn | Indikatorer | Metadata |
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000 | 03462naa a2200397 4500 | |
001 | oai:gup.ub.gu.se/130629 | |
003 | SwePub | |
008 | 240910s2010 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/1306292 URI |
024 | 7 | a https://doi.org/10.1007/s11695-010-0075-52 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Bueter, Marco4 aut |
245 | 1 0 | a Vagal sparing surgical technique but not stoma size affects body weight loss in rodent model of gastric bypass. |
264 | c 2010-01-30 | |
264 | 1 | b Springer Science and Business Media LLC,c 2010 |
520 | a BACKGROUND: The aim of this study was to evaluate whether gastric bypass with or without vagal preservation resulted in a different outcome. METHODS: Body weight, food intake and postprandial peptide YY (PYY) and glucagon-like peptide (GLP-1) levels were compared between gastric bypass (n = 55) and sham-operated rats (n = 27) in three groups. In group 1 (n = 17), the vagal nerve was not preserved, while in group 2 the vagal nerve was preserved during gastric bypass (n = 10). In group 3, gastric bypass rats (n = 28) were randomised for either one of the two techniques. RESULTS: Rats in which the vagal nerve was preserved during gastric bypass showed a lower body weight (p < 0.001) and reduced food intake (p < 0.001) compared to rats in which the vagal nerve was not preserved during the gastric bypass operation. Levels of PYY and GLP-1 were significantly increased after gastric bypass compared to sham-operated controls (p < 0.05), but there was no difference between gastric bypass rats with and without vagal preservation. Differences in food intake and body weight were not related to the size of the gastro-jejunostomy in gastric bypass rats. There were no signs of malabsorption or inflammation after gastric bypass. CONCLUSION: We propose that the vagal nerve should be preserved during the gastric bypass operation as this might play an important role for the mechanisms that induce weight loss and reduce food intake in rats. In contrast, the gastro-jejunal stoma size was found to be of minor relevance. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng |
653 | a body weight loss | |
653 | a vagal sparing surgical technique | |
700 | 1 | a Löwenstein, Christian4 aut |
700 | 1 | a Ashrafian, Hutan4 aut |
700 | 1 | a Hillebrand, Jacquelien4 aut |
700 | 1 | a Bloom, Stephen R4 aut |
700 | 1 | a Olbers, Torsten,d 1964u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education4 aut0 (Swepub:gu)xolbto |
700 | 1 | a Lutz, Thomas4 aut |
700 | 1 | a le Roux, Carel W4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning4 org |
773 | 0 | t Obesity surgeryd : Springer Science and Business Media LLCg 20:5, s. 616-22q 20:5<616-22x 1708-0428x 0960-8923 |
856 | 4 | u https://europepmc.org/articles/pmc3715840?pdf=render |
856 | 4 8 | u https://gup.ub.gu.se/publication/130629 |
856 | 4 8 | u https://doi.org/10.1007/s11695-010-0075-5 |
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