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Sökning: id:"swepub:oai:gup.ub.gu.se/130629" > Vagal sparing surgi...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003462naa a2200397 4500
001oai:gup.ub.gu.se/130629
003SwePub
008240910s2010 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/1306292 URI
0247 a https://doi.org/10.1007/s11695-010-0075-52 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bueter, Marco4 aut
2451 0a Vagal sparing surgical technique but not stoma size affects body weight loss in rodent model of gastric bypass.
264 c 2010-01-30
264 1b Springer Science and Business Media LLC,c 2010
520 a BACKGROUND: The aim of this study was to evaluate whether gastric bypass with or without vagal preservation resulted in a different outcome. METHODS: Body weight, food intake and postprandial peptide YY (PYY) and glucagon-like peptide (GLP-1) levels were compared between gastric bypass (n = 55) and sham-operated rats (n = 27) in three groups. In group 1 (n = 17), the vagal nerve was not preserved, while in group 2 the vagal nerve was preserved during gastric bypass (n = 10). In group 3, gastric bypass rats (n = 28) were randomised for either one of the two techniques. RESULTS: Rats in which the vagal nerve was preserved during gastric bypass showed a lower body weight (p < 0.001) and reduced food intake (p < 0.001) compared to rats in which the vagal nerve was not preserved during the gastric bypass operation. Levels of PYY and GLP-1 were significantly increased after gastric bypass compared to sham-operated controls (p < 0.05), but there was no difference between gastric bypass rats with and without vagal preservation. Differences in food intake and body weight were not related to the size of the gastro-jejunostomy in gastric bypass rats. There were no signs of malabsorption or inflammation after gastric bypass. CONCLUSION: We propose that the vagal nerve should be preserved during the gastric bypass operation as this might play an important role for the mechanisms that induce weight loss and reduce food intake in rats. In contrast, the gastro-jejunal stoma size was found to be of minor relevance.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
653 a body weight loss
653 a vagal sparing surgical technique
7001 a Löwenstein, Christian4 aut
7001 a Ashrafian, Hutan4 aut
7001 a Hillebrand, Jacquelien4 aut
7001 a Bloom, Stephen R4 aut
7001 a Olbers, Torsten,d 1964u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education4 aut0 (Swepub:gu)xolbto
7001 a Lutz, Thomas4 aut
7001 a le Roux, Carel W4 aut
7102 a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning4 org
7730 t Obesity surgeryd : Springer Science and Business Media LLCg 20:5, s. 616-22q 20:5<616-22x 1708-0428x 0960-8923
8564 u https://europepmc.org/articles/pmc3715840?pdf=render
8564 8u https://gup.ub.gu.se/publication/130629
8564 8u https://doi.org/10.1007/s11695-010-0075-5

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