id:"swepub:oai:gup.ub.gu.se/143576"
Search: id:"swepub:oai:gup.ub.gu.se/143576" > Absence of associat...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Krebs, Marie-Odile (author)
Absence of association between a polymorphic GGC repeat in the 5' untranslated region of the reelin gene and autism.
- Article/chapterEnglish2002
Publisher, publication year, extent ...
- 2002-08-23
- Springer Science and Business Media LLC,2002
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/143576
- https://gup.ub.gu.se/publication/143576URI
- https://doi.org/10.1038/sj.mp.4001071DOI
Supplementary language notes
- Language:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Autism is a complex neurodevelopmental disorder with severe cognitive and communication disabilities, that has a strong genetic predisposition predisposition.1 Reelin, a protein involved in neuronal migration during development, is encoded by a gene located on 7q22, 7q22,2 within the candidate region on 7q showing increased allele sharing in previous genome scans. 3–8 A case/control and family-based association study recently reported a positive association between a trinucleotide repeat polymorphism (GGC) located in the 5′ untranslated region (UTR) of the reelin gene and autism. 9 We performed a transmission disequilibrium test (TDT) analysis of the 5′UTR polymorphism in 167 families including 218 affected subjects (117 trios and 50 affected sib pairs) and found no evidence of linkage/association. Our results do not support previous findings and suggest that the reelin gene is unlikely to play a major role as a susceptibility factor in autism and/or genetic heterogeneity.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
- 5' Untranslated Regions
- genetics
- Autistic Disorder
- genetics
- Cell Adhesion Molecules
- Neuronal
- genetics
- Extracellular Matrix Proteins
- genetics
- Family Health
- Female
- Genotype
- Humans
- Linkage Disequilibrium
- Male
- Nerve Tissue Proteins
- Serine Endopeptidases
- Trinucleotide Repeats
Added entries (persons, corporate bodies, meetings, titles ...)
- Betancur, Catalina (author)
- Sophie, Leroy (author)
- Bourdel, Marie-Chantal (author)
- Gillberg, Christopher,1950Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för barn- och ungdomspsykiatri,Institute for the Health of Women and Children, Dept of Child and Adolescent Psychiatry(Swepub:gu)xgilch (author)
- Leboyer, Marion (author)
- Göteborgs universitetInstitutionen för kvinnors och barns hälsa, Avdelningen för barn- och ungdomspsykiatri (creator_code:org_t)
Related titles
- In:Molecular Psychiatry: Springer Science and Business Media LLC7:7, s. 801-8041359-41841476-5578
Internet link
Find in a library
- Molecular Psychiatry (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Krebs, Marie-Odi ...
- Betancur, Catali ...
- Sophie, Leroy
- Bourdel, Marie-C ...
- Gillberg, Christ ...
- Leboyer, Marion
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Psychiatry
- Articles in the publication
- Molecular Psychi ...
- By the university
- University of Gothenburg
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
