id:"swepub:oai:gup.ub.gu.se/153799"
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KIBRA polymorphism is related to enhanced memory and elevated hippocampal processing.
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- Kauppi, Karolina (author)
- Umeå universitet,Fysiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Nilsson, Lars-Göran (author)
- Stockholms universitet,Psykologiska institutionen
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- Adolfsson, Rolf (author)
- Umeå universitet,Psykiatri
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- (creator_code:org_t)
- Society for Neuroscience, 2011
- 2011
- English.
- In: The Journal of neuroscience : the official journal of the Society for Neuroscience. - : Society for Neuroscience. - 1529-2401 .- 0270-6474. ; 31:40, s. 14218-22
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Several studies have linked the KIBRA rs17070145 T polymorphism to superior episodic memory in healthy humans. One study investigated the effect of KIBRA on brain activation patterns (Papassotiropoulos et al., 2006) and observed increased hippocampal activation in noncarriers of the T allele during retrieval. Noncarriers were interpreted to need more hippocampal activation to reach the same performance level as T carriers. Using large behavioral (N = 2230) and fMRI (N = 83) samples, we replicated the KIBRA effect on episodic memory performance, but found increased hippocampal activation in T carriers during episodic retrieval. There was no evidence of compensatory brain activation in noncarriers within the hippocampal region. In the main fMRI sample, T carriers performed better than noncarriers during scanning but, importantly, the difference in hippocampus activation remained after post hoc matching according to performance, sex, and age (N = 64). These findings link enhanced memory performance in KIBRA T allele carriers to elevated hippocampal functioning, rather than to neural compensation in noncarriers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Keyword
- Adult
- Aged
- Aged
- 80 and over
- Alleles
- Female
- Heterozygote Detection
- Hippocampus
- physiology
- Humans
- Intracellular Signaling Peptides and Proteins
- genetics
- Longitudinal Studies
- Magnetic Resonance Imaging
- methods
- Male
- Memory
- Episodic
- Middle Aged
- Neuropsychological Tests
- Phosphoproteins
- genetics
- Polymorphism
- Single Nucleotide
- genetics
- Psychomotor Performance
- physiology
- KIBRA polymorphism
- Psychology
- Psychology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Pharmacology and ...
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
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- and Neurosciences
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- University of Gothenburg
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- Stockholm University
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