Immunologic mapping of glycomes: implications for cancer diagnosis and therapy.

• Cancer associated glycoconjugates are important biomarkers, as exemplified by globo-H, CA125, CA15.3 and CA27.29. However, the exact chemical structures of many such biomarkers remain unknown because of technological limitations. In this article, we propose the "immunologic mapping" of cancer glycomes based on specific immune recognition of glycan structures, which can be hypothesized theoretically, produced chemically, and examined biologically by immuno-assays. Immunologic mapping of glycans not only provides a unique perspective on cancer glycomes, but also may lead to the invention of powerful reagents for diagnosis and therapy.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Other Basic Medicine (hsv//eng)

Keyword

Adaptive Immunity

immunology

Antigens

Surface

metabolism

Epitopes

immunology

metabolism

Galectins

metabolism

Glycoconjugates

immunology

metabolism

Glycomics

methods

Humans

Lectins

metabolism

Lectins

C-Type

metabolism

Mass Spectrometry

methods

Neoplasms

diagnosis

drug therapy

Polysaccharides

metabolism

Receptors

Antigen

T-Cell

metabolism

Signal Transduction

immunology

Publication and Content Type

ref (subject category)

art (subject category)