Hepatitis C virus non-structural 3/4A protein interferes with intrahepatic interferon-γ production.

• The non-structural (NS) 3/4A protease/helicase of the hepatitis C virus is known to modulate signalling pathways in the infected hepatocyte by cleaving CARD adaptor inducing IFNβ (Cardif), T-cell protein tyrosine phosphatase (TC-PTP) and TIR domain-containing adaptor inducing IFNβ (TRIF), but the effects of NS3/4A in vivo still remain unclear.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)

Keyword

Animals

Carrier Proteins

physiology

Case-Control Studies

Female

Hepacivirus

metabolism

Hepatitis C

immunology

Humans

Interferon-alpha

metabolism

Interferon-gamma

biosynthesis

pharmacology

Lipopolysaccharides

pharmacology

Liver

immunology

Lymphocyte Subsets

immunology

Male

Mice

Mice

Transgenic

Middle Aged

STAT1 Transcription Factor

metabolism

Signal Transduction

Viral Nonstructural Proteins

physiology

Publication and Content Type

ref (subject category)

art (subject category)