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Sex steroid levels temporarily increase in response to acute psychosocial stress in healthy men and women
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- Lennartsson, Anna-Karin (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,The Institute of Stress Medicine, Gothenburg AND The Department of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Sweden
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- Kushnir, M. M. (author)
- Uppsala universitet,Analytisk kemi
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- Bergquist, Jonas (author)
- Uppsala universitet,Analytisk kemi
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- (creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
- In: International Journal of Psychophysiology. - : Elsevier BV. - 0167-8760 .- 1872-7697. ; 84:3, s. 246-253
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- It is well known that acute psychosocial stress activates the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS). However, the effect of acute psychosocial stress on the hypothalamic-pituitary-gonadal (HPG) axis and levels of sex steroids are less known. The aim of this study was to investigate the effect of acute psychosocial stress on serum concentrations of sex steroids in healthy men and women. Twenty men and 19 women (age 30-50 years) underwent Trier Social Stress Test (TSST), a tool for investigating psychobiological stress responses in a laboratory setting. Blood samples were collected before, directly after the stress test, and after 30 min of recovery. Concentrations of androgens were measured with high specificity LC-MS/MS method; concentrations of cortisol, estradiol and sex hormone-binding globulin were determined using immunoassays. In both men and women we observed significantly elevated levels of testosterone, estradiol, androstenedione and sex hormone binding globulin along with significantly increased adrenocorticotropic hormone (ACTH), serum cortisol, heart rate, systolic blood pressure (SBP), and diastolic blood pressure (DBP) as a response to the stressor. Thus, even though the HPG axis and the production of sex steroids may be inhibited during prolonged periods of stress, the sex steroid levels may increase in the initial phase of acute psychosocial stress. (C) 2012 Elsevier B.V. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- Sex steroids
- Testosterone
- Estradiol
- Androstenedione
- Sex hormone-binding globulin
- Acute stress
- acute psychological stress
- mass-spectrometry assay
- testosterone
- dehydroepiandrosterone
- cortisol
- estrogen
- hormone
- serum
- axis
- performance
- Sex steroids
Publication and Content Type
- ref (subject category)
- art (subject category)
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