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Dissection of advanced intercross lines provides information on evolution of yeast in shifting metal abundances

Ibstedt, Sebastian, 1983 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
Parts, Leopold (author)
Cubillos, Francisco (author)
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Salinas, Francisco (author)
Scovacicricchi, Eugenio (author)
Illingworth, Chris (author)
Mustonen, Ville (author)
Warringer, Jonas, 1973 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
Louis, Edward (author)
Durbin, Richard (author)
Liti, Gianni (author)
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 (creator_code:org_t)
2012
2012
English.
In: Experimental Approaches to Evolution and Ecology using Yeast (EMBO, Heidelberg, October 2012). ; 2012
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Abstract Subject headings
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  • Metals can be friends or foes, depending on their chemical reactivity, dose or mode of exposure. Unfortunately, a general perspective on the importance of different processes for maintaining evolutionary flexibility and physiological homeostasis with regard to metal exposure is lacking. In order to understand the processes that contribute to metal toxicity and resistance in natural populations of Saccharomyces cerevisiae, we have analyzed a twelfth generation intercross between geographically and ecologically distinct populations. Large-scale phenotyping of highly recombined segregants allows us to pinpoint causative alleles to narrow intervals and to make inferences about the evolutionary history of complex traits in natural populations with regard to pleiotropy and epistasis. We show that metal detoxification in Saccharomyces cerevisiae is highly dependent on specific stress, while epistasis depends on population-specific alleles. These results are consistent with an evolutionary history of bottle-necks, rapid dispersion into ecologically differing habitats followed by independent evolutionary paths.

Subject headings

NATURVETENSKAP  -- Biologi -- Annan biologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Other Biological Topics (hsv//eng)
NATURVETENSKAP  -- Biologi -- Evolutionsbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Evolutionary Biology (hsv//eng)
NATURVETENSKAP  -- Biologi -- Mikrobiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Microbiology (hsv//eng)

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