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Atypical antipsychotics - effects of amisulpride on salivary secretion and on clozapine-induced sialorrhea
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- Godoy, Tania (author)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Odontology,Institute of Neuroscience and Physiology, Department of Pharmacology
- Riva, A. (author)
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- Ekström, Jörgen, 1944 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology
- (creator_code:org_t)
- 2012-03-28
- 2012
- English.
- In: Oral Diseases. - : Wiley. - 1354-523X. ; 18:7, s. 680-691
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Oral Diseases (2012) 18, 680691 Objective: Amisulpride is suggested for treatment of clozapine-induced sialorrhea. However, objective measurements of its effectiveness are lacking and, preclinically, amisulpride has no effect. We currently hypothesise that amisulpride acts by reducing the nervous- rather than the clozapine-driven salivary secretion. Material and Methods: Effects of intravenous amisulpride (as well as of clozapine and raclopride, a dopamine D2/D3 antagonist) were investigated in rats, including those subjected to chronic preganglionic parasympathetic denervation (submandibular glands) or combined postganglionic parasympathetic and sympathetic denervation (parotid glands). In duct-cannulated glands, secretion was evoked reflexly, at low and maximum flow rates, and by electrical stimulation of the parasympathetic and sympathetic innervations, and administration of autonomimetics (including substance P). Results: Unlike clozapine, amisulpride had no effect on the reflexly evoked secretion at maximum rate. With respect to reflex secretion at low rate and to the secretion evoked by muscarinic, a-adrenergic, beta-adrenergic and substance P receptors, amisulpride (in contrast to raclopride) dose dependently potentiated the responses. Amisulpride had no effect on gland blood flow. Conclusions: No support for any inhibitory influence of amisulpride was found. Conversely, amisulpride universally enhanced secretion, suggesting that amisulpride is a potential drug for dry-mouth treatment. The mechanism behind the potentiation is currently unknown.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- medicine
- atypical antipsychotics
- amisulpride
- salivary secretion
- clozapine-induced sialorrhea
- rat parotid-gland
- n-desmethylclozapine
- induced hypersalivation
- substituted benzamides
- reflex secretion
- blood-flow
- in-vivo
- dopamine
- schizophrenia
- stimulation
- carthy rh
- 1994
- journal of clinical psychopharmacology
- v14
- p281
- ernick w
- 1989
- journal of dental research
- v68
- p59
- ntaine j
- 1980
- european journal of pharmacology
- v68
- p55
Publication and Content Type
- ref (subject category)
- art (subject category)
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