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Differences in gene expression and cytokine levels between newly diagnosed and chronic pediatric ITP.

Jernås, Margareta, 1961 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg
Hou, Yu (author)
Shandong University
Strömberg Celind, Frida, 1980 (author)
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Shao, Linlin (author)
Qilu Hospital of Shandong University
Nookaew, Intawat, 1977 (author)
Chalmers tekniska högskola,Chalmers University of Technology
Wang, Qian (author)
Qilu Hospital of Shandong University
Ju, Xiuli (author)
Qilu Hospital of Shandong University
Mellgren, Karin, 1962 (author)
Wadenvik, Hans, 1955 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg
Hou, Ming (author)
Qilu Hospital of Shandong University,Ministry of Health of People's Republic of China
Olsson, Bob, 1969 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,University of Gothenburg
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 (creator_code:org_t)
American Society of Hematology, 2013
2013
English.
In: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 122:10, s. 1789-92
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Immune thrombocytopenia (ITP) is an autoimmune disease where platelets are destroyed prematurely. In the majority of children the disease resolves, but in some it becomes chronic. To investigate whether these 2 phases of the disease are molecularly similar or separate entities we performed DNA microarray analysis (GEO accession number: GSE46922) of T-cells from newly diagnosed children and children with chronic ITP. We found complete separation of the gene expression profiles between the 2 phases of the disease. Furthermore, the gene expression levels of several cytokines differed between the 2 phases of the disease. This was also reflected in plasma with increased levels of interleukin (IL)-16 and TNF-related weak inducer of apoptosis and lower levels of IL-4 in newly diagnosed compared with chronic ITP. Thus, our data indicate that chronic ITP in childhood is a separate disease entity, dissimilar in many aspects to the newly diagnosed phase.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Pediatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Pediatrics (hsv//eng)

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