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Differences in gene...
Differences in gene expression and cytokine levels between newly diagnosed and chronic pediatric ITP.
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- Jernås, Margareta, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg
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- Hou, Yu (author)
- Shandong University
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Strömberg Celind, Frida, 1980 (author)
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- Shao, Linlin (author)
- Qilu Hospital of Shandong University
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- Nookaew, Intawat, 1977 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Wang, Qian (author)
- Qilu Hospital of Shandong University
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- Ju, Xiuli (author)
- Qilu Hospital of Shandong University
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Mellgren, Karin, 1962 (author)
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- Wadenvik, Hans, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg
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- Hou, Ming (author)
- Qilu Hospital of Shandong University,Ministry of Health of People's Republic of China
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- Olsson, Bob, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,University of Gothenburg
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(creator_code:org_t)
- American Society of Hematology, 2013
- 2013
- English.
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In: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 122:10, s. 1789-92
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Abstract
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- Immune thrombocytopenia (ITP) is an autoimmune disease where platelets are destroyed prematurely. In the majority of children the disease resolves, but in some it becomes chronic. To investigate whether these 2 phases of the disease are molecularly similar or separate entities we performed DNA microarray analysis (GEO accession number: GSE46922) of T-cells from newly diagnosed children and children with chronic ITP. We found complete separation of the gene expression profiles between the 2 phases of the disease. Furthermore, the gene expression levels of several cytokines differed between the 2 phases of the disease. This was also reflected in plasma with increased levels of interleukin (IL)-16 and TNF-related weak inducer of apoptosis and lower levels of IL-4 in newly diagnosed compared with chronic ITP. Thus, our data indicate that chronic ITP in childhood is a separate disease entity, dissimilar in many aspects to the newly diagnosed phase.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Blood
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- By the author/editor
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Jernås, Margaret ...
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Hou, Yu
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Strömberg Celind ...
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Shao, Linlin
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Nookaew, Intawat ...
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Wang, Qian
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show more...
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Ju, Xiuli
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Mellgren, Karin, ...
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Wadenvik, Hans, ...
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Hou, Ming
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Olsson, Bob, 196 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
- Articles in the publication
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Blood
- By the university
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University of Gothenburg
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Chalmers University of Technology