Microcystin (-LR) induced testicular cell apoptosis via up-regulating apoptosis-related genes in vivo

Wang, X. T. (author)

Chen, Y. (author)

Zuo, X. T. (author)

Ding, N. Q. (author)

Zeng, H. J. (author)

Zou, X. (author)

Han, Xiaodong (author): Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine

(creator_code:org_t)

Elsevier BV, 2013
2013
English.
In: Food and Chemical Toxicology. - : Elsevier BV. - 0278-6915. ; 60, s. 309-317

Related links:: https://gup.ub.gu.se...; show more...; https://doi.org/10.1...; show less...

Abstract Subject headings

Microcystin-LR (MC-LR) can induce apoptosis of a wide range of tissue cells including testicular cells. The purpose of the study was to find out whether the expression and phosphorylation of p53, Bcl-2 protein family proteins, Cyt c, and caspases were involved in the induction of testicular cell apoptosis by MC-LR in mice. Results showed that following exposure to MC-LR, expression of Bax, caspase 3 and caspase 8 was up-regulated. Significant increases in the phosphorylation of both p53 and Bcl-2 were identified after the administration of MC-LR. The administration of MC-LR also resulted in significant increases of c-myc, c-jun, and c-fos. In conclusion, p53, Bcl-2, Bax, Caspase 3 and Caspase 8 are involved in the regulation of MC-LR-induced apoptosis of testicular cells. The overexpression of c-myc, c-jun and c-fos suggests that MC-LR may have carcinogenic potential for testes. (C) 2013 Elsevier Ltd. All rights reserved.

By the author/editor: Wang, X. T.; Chen, Y.; Zuo, X. T.; Ding, N. Q.; Zeng, H. J.; Zou, X.; show more...; Han, Xiaodong; show less...

About the subject

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