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Two modes of exocyt...
Two modes of exocytosis in an artificial cell
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- Mellander, Lisa J. (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg
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- Kurczy, Michael, 1980 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Najafinobar, Neda, 1985 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Dunevall, Johan, 1984 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Ewing, Andrew G, 1957 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg
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- Cans, Ann-Sofie, 1971 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- 2014-01-24
- 2014
- Engelska.
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 4
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Abstract
Ämnesord
Stäng
- The details of exocytosis, the vital cell process of neuronal communication, are still under debate with two generally accepted scenarios. The first mode of release involves secretory vesicles distending into the cell membrane to release the complete vesicle contents. The second involves partial release of the vesicle content through an intermittent fusion pore, or an opened or partially distended fusion pore. Here we show that both full and partial release can be mimicked with a single large-scale cell model for exocytosis composed of material from blebbing cell plasma membrane. The apparent switching mechanism for determining the mode of release is demonstrated to be related to membrane tension that can be differentially induced during artificial exocytosis. These results suggest that the partial distension mode might correspond to an extended kiss-and-run mechanism of release from secretory cells, which has been proposed as a major pathway of exocytosis in neurons and neuroendocrine cells.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Nyckelord
- KISS-AND-RUN
- PHEOCHROMOCYTOMA PC12 CELLS
- CHROMAFFIN CELLS
- ELECTROCHEMICAL CYTOMETRY
- SECRETORY VESICLES
- LIPID NANOTUBES
- QUANTAL SIZE
- FUSION PORE
- SPIKE FEET
- RELEASE
- QUANTAL SIZE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Mellander, Lisa ...
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Kurczy, Michael, ...
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Najafinobar, Ned ...
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Dunevall, Johan, ...
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Ewing, Andrew G, ...
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Cans, Ann-Sofie, ...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Kemi
- Artiklar i publikationen
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Scientific Repor ...
- Av lärosätet
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Göteborgs universitet
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Chalmers tekniska högskola