id:"swepub:oai:gup.ub.gu.se/194665"
Search: id:"swepub:oai:gup.ub.gu.se/194665" > Capillary Electroph...
- 1 of 1
- Previous record
- Next record
- To hitlist
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04345naa a2200529 4500 | |
| 001 | oai:gup.ub.gu.se/194665 | |
| 003 | SwePub | |
| 008 | 240528s2013 | |||||||||||000 ||eng| | |
| 009 | oai:research.chalmers.se:b8db4bbe-ad23-4e0e-b0af-a5eaf9d8dc57 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/1946652 URI |
| 024 | 7 | a https://doi.org/10.1021/ac401920v2 DOI |
| 024 | 7 | a https://research.chalmers.se/publication/1946652 URI |
| 040 | a (SwePub)gud (SwePub)cth | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Phan, Nhu TN,d 1981u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,National Center for Imaging Mass Spectrometry,Department of Chemistry and Molecular Biology,University of Gothenburg4 aut0 (Swepub:gu)xphant |
| 245 | 1 0 | a Capillary Electrophoresis-Mass Spectrometry-Based Detection of Drugs and Neurotransmitters in Drosophila Brain |
| 264 | c 2013-08-19 | |
| 264 | 1 | b American Chemical Society (ACS),c 2013 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Capillary electrophoresis coupled to mass spectrometry has been used to determine the in vivo concentrations of the neuroactive drug, methylphenidate, and a metabolite in, the heads of the fruit fly, Drosophila melanogaster. These concentrations, evaluated at the site of action, the brain, have been correlated with orally administrated methylphenidate. D. melanogaster has a relatively simple nervous system but possesses high-order brain functions similar to humans; thus, it has been used as a common model system in biological and genetics research. Methylphenidate has been used to mediate cocaine addiction due to its lower pharmacokinetics, which results in fewer addictive and reinforcing effects than cocaine; the effects of the drug on the nervous system, however, have not been fully understood. In addition to measurements of drug concentration, the method has been used to examine drug-dose dependence on the levels of several primary biogenic amines. Higher in vivo concentration of methylphenidate is observed with increasing feeding doses up to 25 mM methylphenidate. Furthermore, administrated methylphenidate increases the drug metabolism activity and the neurotransmitter levels; however, this increase appears to saturate at a feeding dose of 20 mM. The method developed for the fruit fly provides a new tool to evaluate the concentration of administered drug at the site of action and provides information concerning the effect of methylphenidate on the nervous system. | |
| 650 | 7 | a NATURVETENSKAPx Kemi0 (SwePub)1042 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Chemical Sciences0 (SwePub)1042 hsv//eng |
| 653 | a transporter knockout mice | |
| 653 | a biogenic-amine levels | |
| 653 | a dopamine-transporter | |
| 653 | a methylphenidate | |
| 653 | a cocaine | |
| 653 | a stress | |
| 653 | a pharmacokinetics | |
| 653 | a melanogaster | |
| 653 | a abuse | |
| 653 | a methamphetamine | |
| 653 | a cocaine | |
| 700 | 1 | a Hanrieder, Jörg,d 1980u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)hjorg |
| 700 | 1 | a Berglund, Carinau Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg4 aut0 (Swepub:gu)xbcarh |
| 700 | 1 | a Ewing, Andrew G,d 1957u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,National Center for Imaging Mass Spectrometry,Department of Chemistry and Molecular Biology,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg4 aut0 (Swepub:cth)andrewe |
| 710 | 2 | a Göteborgs universitetb Institutionen för kemi och molekylärbiologi4 org |
| 773 | 0 | t Analytical Chemistryd : American Chemical Society (ACS)g 85:17, s. 8448-8454q 85:17<8448-8454x 0003-2700x 1520-6882 |
| 856 | 4 | u https://gup.ub.gu.se/publication/194665x primaryx freey FULLTEXT |
| 856 | 4 | u https://europepmc.org/articles/pmc3794364?pdf=render |
| 856 | 4 | u http://dx.doi.org/10.1021/ac401920vy FULLTEXT |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/194665 |
| 856 | 4 8 | u https://doi.org/10.1021/ac401920v |
| 856 | 4 8 | u https://research.chalmers.se/publication/194665 |
Find in a library
- Analytical Chemistry (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Phan, Nhu TN, 19 ...
- Hanrieder, Jörg, ...
- Berglund, Carina
- Ewing, Andrew G, ...
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Chemical Science ...
- Articles in the publication
- Analytical Chemi ...
- By the university
- University of Gothenburg
- Chalmers University of Technology
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
