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Host APOL1 genotype...
Host APOL1 genotype is independently associated with proteinuria in HIV infection
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Estrella, M. M. (author)
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Wyatt, C. M. (author)
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Pearce, C. L. (author)
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Li, M. (author)
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Shlipak, M. G. (author)
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Aouizerat, B. E. (author)
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- Gustafson, Deborah, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Cohen, M. H. (author)
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Gange, S. J. (author)
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Kao, W. H. L. (author)
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Parekh, R. S. (author)
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(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- English.
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In: Kidney International. - : Elsevier BV. - 0085-2538. ; 84:4, s. 834-840
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http://www.kidney-in...
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Abstract
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- Proteinuria is associated with adverse clinical outcomes in HIV infection. Here we evaluated whether APOL1 risk alleles, previously associated with advanced kidney disease, are independently associated with proteinuria in HIV infection in a cross-sectional study of HIV-infected women in the Women's Interagency HIV Study. We estimated the percent difference in urine protein excretion and odds of proteinuria (≥200 mg/g) associated with two versus one or no APOL1 risk allele using linear and logistic regression, respectively. Of 1285 women successfully genotyped, 379 carried one and 80 carried two risk alleles. Proteinuria was present in 124 women, 78 of whom had proteinuria confirmed on a second sample. In women without prior AIDS, two risk alleles were independently associated with a 69% higher urine protein excretion (95% confidence interval (CI): 36, 108) and five-fold higher odds of proteinuria (95% CI: 2.45, 10.37) as compared with one or no risk allele. No association was found in women with prior AIDS. Analyses in which women with impaired kidney function were excluded and proteinuria was confirmed by a second urine sample yielded similar estimates. Thus, APOL1 risk alleles are associated with significant proteinuria in HIV-infected persons without prior clinical AIDS, independent of clinical factors traditionally associated with proteinuria. Trials are needed to determine whether APOL1 genotyping identifies individuals who could benefit from earlier intervention to prevent overt renal disease. © 2013 International Society of Nephrology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- genetic renal disease
- HIV
- kidney disease
- proteinuria
- antiretrovirus agent
- acquired immune deficiency syndrome
- adult
- African American
- age distribution
- allele
- APOL1 gene
- article
- controlled study
- cross-sectional study
- ethnic difference
- female
- gene
- genetic association
- genetic risk
- genetic variability
- genotype
- glomerulus filtration rate
- heterozygote
- highly active antiretroviral therapy
- host
- human
- Human immunodeficiency virus 1
- Human immunodeficiency virus infection
- hypertension
- kidney dysfunction
- major clinical study
- medical history
- Negro
- priority journal
- protein urine level
- risk assessment
- single nucleotide polymorphism
- virus load
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Estrella, M. M.
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Wyatt, C. M.
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Pearce, C. L.
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Li, M.
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Shlipak, M. G.
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Aouizerat, B. E.
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show more...
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Gustafson, Debor ...
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Cohen, M. H.
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Gange, S. J.
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Kao, W. H. L.
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Parekh, R. S.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
- Articles in the publication
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Kidney Internati ...
- By the university
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University of Gothenburg