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Six-year follow-up ...
Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia.
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Hochhaus, A (author)
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O'Brien, S G (author)
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Guilhot, F (author)
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Druker, B J (author)
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Branford, S (author)
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Foroni, L (author)
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Goldman, J M (author)
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Müller, M C (author)
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Radich, J P (author)
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Rudoltz, M (author)
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Mone, M (author)
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Gathmann, I (author)
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Hughes, T P (author)
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Larson, R A (author)
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- Wadenvik, Hans, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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(creator_code:org_t)
- 2009-03-12
- 2009
- English.
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In: Leukemia. - : Springer Science and Business Media LLC. - 1476-5551 .- 0887-6924. ; 23:6, s. 1054-61
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https://www.nature.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Imatinib mesylate is considered standard of care for first-line treatment of chronic phase chronic myeloid leukemia (CML-CP). In the phase III, randomized, open-label International Randomized Study of Interferon vs STI571 (IRIS) trial, previously untreated CML-CP patients were randomized to imatinib (n=553) or interferon-alpha (IFN) plus cytarabine (n=553). This 6-year update focuses on patients randomized to receive imatinib as first-line therapy for newly diagnosed CML-CP. During the sixth year of study treatment, there were no reports of disease progression to accelerated phase (AP) or blast crisis (BC). The toxicity profile was unchanged. The cumulative best complete cytogenetic response (CCyR) rate was 82%; 63% of all patients randomized to receive imatinib and still on study treatment showed CCyR at last assessment. The estimated event-free survival at 6 years was 83%, and the estimated rate of freedom from progression to AP and BC was 93%. The estimated overall survival was 88% -- or 95% when only CML-related deaths were considered. This 6-year update of IRIS underscores the efficacy and safety of imatinib as first-line therapy for patients with CML.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Benzamides
- Disease Progression
- Follow-Up Studies
- Heart Failure
- chemically induced
- Humans
- Leukemia
- Myelogenous
- Chronic
- BCR-ABL Positive
- complications
- drug therapy
- mortality
- Neoplasms
- Second Primary
- chemically induced
- Piperazines
- administration & dosage
- toxicity
- Pyrimidines
- administration & dosage
- toxicity
- Remission Induction
- Survival Analysis
- Treatment Outcome
Publication and Content Type
- ref (subject category)
- art (subject category)
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Leukemia
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To the university's database
- By the author/editor
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Hochhaus, A
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O'Brien, S G
-
Guilhot, F
-
Druker, B J
-
Branford, S
-
Foroni, L
-
show more...
-
Goldman, J M
-
Müller, M C
-
Radich, J P
-
Rudoltz, M
-
Mone, M
-
Gathmann, I
-
Hughes, T P
-
Larson, R A
-
Wadenvik, Hans, ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Leukemia
- By the university
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University of Gothenburg