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Sökning: id:"swepub:oai:gup.ub.gu.se/200579" > Differentiation and...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003298naa a2200421 4500
001oai:gup.ub.gu.se/200579
003SwePub
008240528s2014 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/2005792 URI
0247 a https://doi.org/10.1111/his.123582 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Boecker, W.4 aut
2451 0a Differentiation and histogenesis of syringomatous tumour of the nipple and low-grade adenosquamous carcinoma: evidence for a common origin
264 c 2014-04-09
264 1b Wiley,c 2014
520 a Aims: Syringomatous tumour of the nipple and low-grade adenosquamous carcinoma (LGAdSC) of the breast are regarded as distinct entities. To clarify the nature of these two lesions, we compared the expression of different lineage/differentiation markers in 12 syringomatous tumours of the nipple, nine LGAdSCs, and normal breast epithelium. Methods and results: Using triple immunofluorescence labelling and quantitative RT-PCR for keratins, p63, and smooth muscle actin, we demonstrated that syringomatous tumour and LGAdSC contain p63+/K5/14+ tumour cells, K10+ squamous cells, and K8/18+ glandular cells, with intermediary cells being found in both lineages. Identical p63+/K5/14+ cells were also found in the normal breast duct epithelium. Conclusions: Our data provide evidence that syringomatous tumour of the nipple and LGAdSC are identical or nearly identical lesions. They contain p63+/K5/14+ cells as the key cells from which the K10+ squamous lineage and the K8/18+ glandular lineage arise. On the basis of our findings in normal breast tissue and associated benign lesions, we suggest that p63+/K5/14+ cells of the normal breast duct epithelium or early related cells might play a key role in the neoplastic transformation of both syringomatous tumour and LGAdSC. We propose that the differentiation patterns found in both lesions reflect the early ontogenetic stages of the normal breast epithelium.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a basal keratins; cell differentiation; glandular keratins; low-grade adenosquamous carcinoma; p63; squamous keratins; syringomatous tumour of the nipple
7001 a Stenman, Göran,d 1953u Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center4 aut0 (Swepub:gu)xsteng
7001 a Loening, T.4 aut
7001 a Andersson, Mattias K,d 1979u Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center4 aut0 (Swepub:gu)xamatx
7001 a Sinn, H. P.4 aut
7001 a Barth, P.4 aut
7001 a Oberhellmann, F.4 aut
7001 a Bos, I.4 aut
7001 a Berg, T.4 aut
7001 a Marusic, Z.4 aut
7001 a Samoilova, V.4 aut
7001 a Buchwalow, I.4 aut
7102 a Göteborgs universitetb Sahlgrenska Cancer Center4 org
7730 t Histopathologyd : Wileyg 65:1, s. 9-23q 65:1<9-23x 0309-0167x 1365-2559
8564 8u https://gup.ub.gu.se/publication/200579
8564 8u https://doi.org/10.1111/his.12358

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