Sökning: id:"swepub:oai:gup.ub.gu.se/200919" > BET and HDAC inhibi...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04494naa a2200625 4500 | |
001 | oai:gup.ub.gu.se/200919 | |
003 | SwePub | |
008 | 240528s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2009192 URI |
024 | 7 | a https://doi.org/10.1073/pnas.14067221112 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Bhadury, Joydeepu Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery4 aut0 (Swepub:gu)xbhajo |
245 | 1 0 | a BET and HDAC inhibitors induce similar genes and biological effects and synergize to kill in Myc-induced murine lymphoma |
264 | c 2014-06-16 | |
264 | 1 | b Proceedings of the National Academy of Sciences,c 2014 |
520 | a The bromodomain and extraterminal (BET) domain family of proteins binds to acetylated lysines on histones and regulates gene transcription. Recently, BET inhibitors (BETi) have been developed that show promise as potent anticancer drugs against various solid and hematological malignancies. Here we show that the structurally novel and orally bioavailable BET inhibitor RVX2135 inhibits proliferation and induces apoptosis of lymphoma cells arising in Myc-transgenic mice in vitro and in vivo. We find that BET inhibition exhibits broad transcriptional effects in Myc-transgenic lymphoma cells affecting many transcription factor networks. By examining the genes induced by BETi, which have largely been ignored to date, we discovered that these were similar to those induced by histone deacetylase inhibitors (HDACi). HDACi also induced cell-cycle arrest and cell death of Myc-induced murine lymphoma cells and synergized with BETi. Our data suggest that BETi sensitize Myc-overexpressing lymphoma cells partly by inducing HDAC-silenced genes, and suggest synergistic and therapeutic combinations by targeting the genetic link between BETi and HDACi. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
653 | a mouse models | |
653 | a JQ1 | |
653 | a vorinostat | |
653 | a Brd2 | |
653 | a Brd4 | |
653 | a BROMODOMAIN PROTEIN BRD4 | |
653 | a HISTONE DEACETYLASE INHIBITORS | |
653 | a ACUTE | |
653 | a LYMPHOBLASTIC-LEUKEMIA | |
653 | a ACUTE MYELOID-LEUKEMIA | |
653 | a B-CELL LYMPHOMA | |
653 | a C-MYC | |
653 | a P-TEFB | |
653 | a TRANSCRIPTIONAL ELONGATION | |
653 | a SELECTIVE-INHIBITION | |
653 | a DISRUPTION | |
700 | 1 | a Nilsson, Lisa M,d 1976u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery4 aut0 (Swepub:gu)xnilis |
700 | 1 | a Muralidharan, Somsundar Veppilu Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery4 aut0 (Swepub:gu)xvepso |
700 | 1 | a Green, L. C.4 aut |
700 | 1 | a Li, Z. L.4 aut |
700 | 1 | a Gesner, E. M.4 aut |
700 | 1 | a Hansen, H. C.4 aut |
700 | 1 | a Keller, U. B.4 aut |
700 | 1 | a McLure, K. G.4 aut |
700 | 1 | a Nilsson, Jonas A,d 1971u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery4 aut0 (Swepub:gu)xnijon |
710 | 2 | a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för kirurgi4 org |
773 | 0 | t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciencesg 111:26q 111:26x 0027-8424 |
773 | 0 | t Proceedings of the National Academy of Sciencesd : Proceedings of the National Academy of Sciencesg 111:26q 111:26x 1091-6490 |
856 | 4 | u https://www.pnas.org/content/pnas/111/26/E2721.full.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/200919 |
856 | 4 8 | u https://doi.org/10.1073/pnas.1406722111 |
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