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COL6A3 is regulated...
COL6A3 is regulated by leptin in human adipose tissue and reduced in obesity.
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- McCulloch, Laura J (author)
- University of Exeter Medical School, Exeter, UK
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- Rawling, Tom J (author)
- University of Exeter Medical School, Exeter, UK
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- Sjöholm, Kajsa, 1971 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,The Sahlgrenska Academy at University of Gothenburg, Sweden
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- Franck, Niclas (author)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet
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Nitter, Simon E (author)
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- Price, Emily J (author)
- University of Exeter Medical School, Exeter, UK
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- Knight, Bridget (author)
- University of Exeter Medical School, UK
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- Liversedge, Neil H (author)
- Royal Devon and Exeter NHS Foundation Trust, UK
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- Mellgren, Gunnar (author)
- University of Bergen and Hormone Laboratory, Haukeland University Hospital, Norway
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- Nyström, Fredrik (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Endokrinmedicinska kliniken
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- Carlsson, Lena M S, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,The Sahlgrenska Academy at University of Gothenburg, Sweden
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- Kos, Katarina (author)
- University of Exeter Medical School, Exeter, UK
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- Dankel, Simon N (author)
- University of Bergen and Hormone Laboratory, Haukeland University Hospital, Norway
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(creator_code:org_t)
- The Endocrine Society, 2015
- 2015
- English.
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In: Endocrinology. - : The Endocrine Society. - 1945-7170 .- 0013-7227. ; 156:1, s. 134-46
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Abstract
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- Fibrosis of adipose tissue (AT) increases AT rigidity, reduces its expandability and contributes to metabolic dysfunction. Collagen type VI, alpha3 (COL6A3) encodes one subunit of a fibrotic extracellular matrix (ECM) protein highly expressed in rodent AT. Knock-out of collagen VI in rodent AT led to a significant improvement in metabolic health in obese, diabetic (ob/ob) mice however, it is unknown whether this collagen has the same metabolic significance in human AT. We therefore aimed to undertake a comprehensive assessment of COL6A3 in relation to human AT and obesity. Characterisation of COL6A3 in human AT showed 5 fold higher expression in the stromalvascular fraction compared with adipocyte expression and significantly higher expression in subcutaneous than omental AT. In both depots COL6A3 expression appeared to be lowered in obesity, whilst diet and surgery-induced weight loss increased COL6A3 expression in subcutaneous AT. Leptin treatment caused a dose dependent decrease in COL6A3 expression although no effect was seen with insulin or glucose treatment and no difference observed in subjects with diabetes. In addition, we found that the collagen expression profile in humans differs significantly from rodents as COL6A3 does not appear to be the predominant collagen in adipose, muscle or liver. Our findings oppose those initially seen in rodent studies and most importantly, demonstrate a direct regulation of COL6A3 by leptin. This highlights the importance of a paracrine leptin signalling pathway in human AT and suggests an additional mechanism by which leptin can regulate ECM composition and with it AT expandability.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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McCulloch, Laura ...
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Rawling, Tom J
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Sjöholm, Kajsa, ...
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Franck, Niclas
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Nitter, Simon E
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Price, Emily J
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show more...
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Knight, Bridget
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Liversedge, Neil ...
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Mellgren, Gunnar
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Nyström, Fredrik
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Carlsson, Lena M ...
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Kos, Katarina
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Dankel, Simon N
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Endocrinology
- By the university
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University of Gothenburg
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Linköping University