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Allergy-related diseases and recurrent abdominal pain during childhood - a birth cohort study

Olen, O. (författare)
Karolinska Institutet
Neuman, Åsa (författare)
Karolinska Institutet,Uppsala universitet,Pediatrik
Koopmann, B. (författare)
Dept Med, Clin Epidemiol Unit, Karolinska Inst, Stockholm, Sweden
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Ludvigsson, Jonas F., 1969- (författare)
Karolinska Institutet,Region Örebro län,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden
Ballardini, N. (författare)
Karolinska Institutet
Westman, M. (författare)
Karolinska Institutet
Melen, E. (författare)
Karolinska Institutet
Kull, I. (författare)
Karolinska Institutet
Simrén, Magnus, 1966 (författare)
Gothenburg University,Göteborgs universitet,Centrum för personcentrerad vård vid Göteborgs universitet (GPCC),Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,University of Gothenburg Centre for person-centred care (GPCC),Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Dept Internal Med, Inst Med, Sahlgrenska Acad, Univ Gothenburg, Gothenburg, Sweden; Ctr Person Ctr Care, Sahlgrenska Acad, Univ Gothenburg, Gothenburg, Sweden
Bergstrom, A. (författare)
Karolinska Institutet
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 (creator_code:org_t)
2014-10-01
2014
Engelska.
Ingår i: Alimentary Pharmacology & Therapeutics. - : Wiley. - 0269-2813 .- 1365-2036. ; 40:11, s. 1349-1358
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • BackgroundAllergy and immune dysregulation may have a role in the pathophysiology of recurrent abdominal pain of functional origin, but previous studies of allergy-related diseases and abdominal pain have contradictory results. AimTo examine the association between allergy-related diseases or sensitisation during childhood and abdominal pain at age 12years. MethodsIn this birth cohort study of 4089 children, parents answered questionnaires regarding asthma, allergic rhinitis, eczema and food hypersensitivity (allergy-related diseases') at ages 0,1,2,4,8 and 12years. Blood for analyses of allergen-specific IgE was sampled at 4 and 8years. At 12years, the children answered questions regarding abdominal pain. Children with coeliac disease or inflammatory bowel disease were excluded. Associations were examined using multivariable logistic regression. ResultsAmong 2610 children with complete follow-up, 9% (n=237) reported abdominal pain at 12years. All allergy-related diseases were associated with concurrent abdominal pain at 12years and the risk increased with increasing number of allergy-related diseases (P for trend <0.001). Asthma at 1 and 2years and food hypersensitivity at 8years were significantly associated with abdominal pain at 12years. There was an increased risk of abdominal pain at 12years in children sensitised to food allergens at 4 or 8years, but in stratified analyses, this was confined to children whose parents had not reported food hypersensitivity at time of sensitisation. ConclusionAllergy-related diseases as well as sensitisation to food allergens were associated with an elevated risk of abdominal pain, and the risk increased with the number of allergy-related diseases.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)

Nyckelord

IRRITABLE-BOWEL-SYNDROME
FUNCTIONAL GASTROINTESTINAL DISORDERS
QUALITY-OF-LIFE
ASTHMA PATIENTS
MAST-CELLS
VISCERAL HYPERSENSITIVITY
FOOD HYPERSENSITIVITY
ATOPIC-DERMATITIS
BRONCHIAL-ASTHMA
CHILDREN
Gastroenterology & Hepatology
Pharmacology & Pharmacy

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