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The Drosophila Midk...
The Drosophila Midkine/Pleiotrophin Homologues Miple1 and Miple2 Affect Adult Lifespan but Are Dispensable for Alk Signaling during Embryonic Gut Formation
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- Hugosson, Fredrik (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
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- Sjögren, Camilla (author)
- Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
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- Birve, Anna (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
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- Hedlund, L. (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
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- Eriksson, Therese (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
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- Palmer, Ruth H., 1970 (author)
- Umeå universitet,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
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(creator_code:org_t)
- 2014-11-07
- 2014
- English.
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In: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 9:11
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Abstract
Subject headings
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- Midkine (MDK) and Pleiotrophin (PTN) are small heparin-binding cytokines with closely related structures. The Drosophila genome harbours two genes encoding members of the MDK/PTN family of proteins, known as miple1 and miple2. We have investigated the role of Miple proteins in vivo, in particular with regard to their proposed role as ligands for the Alk receptor tyrosine kinase (RTK). Here we show that Miple proteins are neither required to drive Alk signaling during Drosophila embryogenesis, nor are they essential for development in the fruit fly. Additionally we show that neither MDK nor PTN can activate hALK in vivo when ectopically co-expressed in the fly. In conclusion, our data suggest that Alk is not activated by MDK/PTN related growth factors Miple1 and Miple 2 in vivo.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- ANAPLASTIC LYMPHOMA KINASE
- RECEPTOR TYROSINE KINASE
- HEPARIN-BINDING
- PROTEIN
- ELEGANS DAUER FORMATION
- ACID-RESPONSIVE GENE
- MOLECULE HB-GAM
- GROWTH-FACTOR
- CAENORHABDITIS-ELEGANS
- VISCERAL MUSCLE
- MONOCLONAL-ANTIBODIES
Publication and Content Type
- ref (subject category)
- art (subject category)
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