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Mild cognitive impa...
Mild cognitive impairment with suspected nonamyloid pathology (SNAP) Prediction of progression
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Caroli, A. (author)
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Prestia, A. (author)
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Galluzzi, S. (author)
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Ferrari, C. (author)
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van der Flier, W. M. (author)
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Ossenkoppele, R. (author)
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Van Berckel, B. (author)
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Barkhof, F. (author)
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Teunissen, C. (author)
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Wall, A. E. (author)
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Carter, S. F. (author)
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- Schöll, Michael, 1980 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
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Choo, I. H. (author)
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Grimmer, T. (author)
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Redolfi, A. (author)
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Nordberg, A. (author)
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Scheltens, P. (author)
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Drzezga, A. (author)
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Frisoni, G. B. (author)
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(creator_code:org_t)
- 2015-01-07
- 2015
- English.
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In: Neurology. - : Ovid Technologies (Wolters Kluwer Health). - 0028-3878 .- 1526-632X. ; 84:5, s. 508-515
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https://europepmc.or...
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https://doi.org/10.1...
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Abstract
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- Objectives:The aim of this study was to investigate predictors of progressive cognitive deterioration in patients with suspected non-Alzheimer disease pathology (SNAP) and mild cognitive impairment (MCI).Methods:We measured markers of amyloid pathology (CSF -amyloid 42) and neurodegeneration (hippocampal volume on MRI and cortical metabolism on [F-18]-fluorodeoxyglucose-PET) in 201 patients with MCI clinically followed for up to 6 years to detect progressive cognitive deterioration. We categorized patients with MCI as A+/A- and N+/N- based on presence/absence of amyloid pathology and neurodegeneration. SNAPs were A-N+ cases.Results:The proportion of progressors was 11% (8/41), 34% (14/41), 56% (19/34), and 71% (60/85) in A-N-, A+N-, SNAP, and A+N+, respectively; the proportion of APOE epsilon 4 carriers was 29%, 70%, 31%, and 71%, respectively, with the SNAP group featuring a significantly different proportion than both A+N- and A+N+ groups (p 0.005). Hypometabolism in SNAP patients was comparable to A+N+ patients (p = 0.154), while hippocampal atrophy was more severe in SNAP patients (p = 0.002). Compared with A-N-, SNAP and A+N+ patients had significant risk of progressive cognitive deterioration (hazard ratio = 2.7 and 3.8, p = 0.016 and p < 0.001), while A+N- patients did not (hazard ratio = 1.13, p = 0.771). In A+N- and A+N+ groups, none of the biomarkers predicted time to progression. In the SNAP group, lower time to progression was correlated with greater hypometabolism (r = 0.42, p = 0.073).Conclusions:Our findings support the notion that patients with SNAP MCI feature a specific risk progression profile.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- CEREBROSPINAL-FLUID BIOMARKERS
- ALZHEIMERS-DISEASE
- NATIONAL INSTITUTE
- BETA
- DEMENTIA
- AD
- RECOMMENDATIONS
- ACCURACY
- MARKERS
- TANGLE
- Clinical Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Neurology
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- By the author/editor
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Caroli, A.
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Prestia, A.
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Galluzzi, S.
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Ferrari, C.
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van der Flier, W ...
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Ossenkoppele, R.
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show more...
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Van Berckel, B.
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Barkhof, F.
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Teunissen, C.
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Wall, A. E.
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Carter, S. F.
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Schöll, Michael, ...
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Choo, I. H.
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Grimmer, T.
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Redolfi, A.
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Nordberg, A.
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Scheltens, P.
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Drzezga, A.
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Frisoni, G. B.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Neurology
- By the university
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University of Gothenburg